VPC285785
VPC285785 is an orally active SARS-CoV-2 main protease inhibitor with an IC50 of 0.8 μM and a Kd of 2.7 μM. VPC285785 functionally inhibits the viral main protease-mediated processing of viral polyprotein precursors required for viral replication. VPC285785 reduces viral loads in the liver, brain and spleen tissues of MHV-infected mice. VPC285785 is applicable to the research of coronavirus infections.
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- CAS No.: 2759276-10-1
- Formule: C24H25F2N5O3
- Masse moléculaire:469.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
VPC285785 (10 μM) exerts weak inhibitory effects on human cathepsin L (CatL), with only 15% inhibition observed at the concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/CJ (female, 8-10 weeks old, 18.5-26.5 g, intranasal infection with MHV-A59)[1]
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Dosage:150 mg/kg
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Administration:p.o.; once daily; 3 days (day 1, 2, 3 post-infection)
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Result:Reduced liver enzyme levels: alanine transaminase (ALT) 65.5 U/L, aspartate aminotransferase (AST) 126.0 U/L, and total protein (TP) 54.16 g/L.
Showed less pronounced decrease in blood urea nitrogen (BUN) levels.
Lowered white blood cell (WBC) counts.
Achieved statistically significant reduction in viral load in the liver, brain, and spleen; no significant differences in viral load observed in the lung, heart, or kidney.
Chemical Information
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CAS No. 2759276-10-1
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Masse moléculaire 469.48
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Formule C24H25F2N5O3
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SMILES
FC1=CC(F)=C(C=C(C(N2C[C@H](C3(C)C)[C@H]3[C@H]2C(N[C@H](C#N)C[C@@H]4CCNC4=O)=O)=O)N5)C5=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VPC285785 Related Classifications
HY-181983 Related Classifications
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