(Z)-Azoxystrobin
Based on 1 Customer Validation
(Z)-Azoxystrobin is an enantiomer of Azoxystrobin. Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
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- Pureté: 98.10%
- CAS No.: 143130-94-3
- Formule: C22H17N3O5
- Masse moléculaire:403.39
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Stockage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
>10 μM
Compound: MMV021057
|
Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DMEM (10% FBS) media using TC plates, by Resazurin F(560/590)
Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DMEM (10% FBS) media using TC plates, by Resazurin F(560/590)
|
10.6019/CHEMBL4296181 |
| L6 | IC50 |
50.32 μM
Compound: DNDI1511705
|
DNDI: Cytotoxicity against L-6 rat myoblasts from skeletal muscle cells
DNDI: Cytotoxicity against L-6 rat myoblasts from skeletal muscle cells
|
10.6019/CHEMBL1862790 |
| MRC5 | CC50 |
>28 μM
Compound: MMV021057
|
MRC5 CC50 (uM) Cytotoxicity
MRC5 CC50 (uM) Cytotoxicity
|
10.6019/CHEMBL3832761 |
Chemical Information
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CAS No. 143130-94-3
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Appearance Solid
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Masse moléculaire 403.39
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Formule C22H17N3O5
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Color Off-white to light brown
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SMILES
CO/C=C(C1=C(OC2=NC=NC(OC3=C(C=CC=C3)C#N)=C2)C=CC=C1)/C(OC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Enock Mpofu, et al. Azoxystrobin amine: A novel azoxystrobin degradation product from Bacillus licheniformis strain TAB7. Chemosphere. 2021 Jun;273:129663. [Content Brief]
[4]. Zhang Q, et al. Oral azoxystrobin driving the dynamic change in resistome by disturbing the stability of the gut microbiota of Enchytraeus crypticus. J Hazard Mater. 2022 Feb 5;423(Pt B):127252. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)