1. Metabolic Enzyme/Protease
  2. Mineralocorticoid Receptor
  3. Canrenoate potassium

Canrenoate potassium (Synonyms: Aldadiene potassium; SC-14266)

Cat. No.: HY-B1582A
Handling Instructions

Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension.

For research use only. We do not sell to patients.

Canrenoate potassium Chemical Structure

Canrenoate potassium Chemical Structure

CAS No. : 2181-04-6

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Description

Canrenoate (Aldadiene) potassium, a prodrug that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3].

In Vivo

Potassium canrenoate has been shown to cause in rats a dose-dependent increase in myelogenous leukemia and statistically significant increases in malignant tumor of the liver, thyroid, brain and mammary gland[2][3].
Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.56

Formula

C₂₂H₂₉KO₄

CAS No.
SMILES

C[[email protected]@]12[[email protected]@](CCC(O[K])=O)(O)CC[[email protected]@]1([H])[[email protected]]3([H])C=CC4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])CC2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CanrenoateAldadiene SC-14266SC14266SC 14266SC-14266Mineralocorticoid ReceptorcompetitivediuretichypertensioncardiacfibrosisInhibitorinhibitorinhibit

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Canrenoate potassium
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HY-B1582A
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