Canrenoate potassium
Based on 1 Customer Validation
Canrenoate (Aldadiene) potassium, a proagent that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 2181-04-6
- Formula: C22H29KO4
- Molecular Weight:396.56
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2181-04-6
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Appearance Solid
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Molecular Weight 396.56
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Formula C22H29KO4
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Color White to yellow
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SMILES
C[C@@]12[C@@](CCC(O[K])=O)(O)CC[C@@]1([H])[C@]3([H])C=CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O
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Synonyms
Aldadiene potassium; SC-14266
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (252.17 mM; ultrasonic and warming and heat to 60°C)
DMSO : 2 mg/mL (5.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5217 mL | 12.6084 mL | 25.2169 mL | 63.0422 mL |
| 5 mM | 0.5043 mL | 2.5217 mL | 5.0434 mL | 12.6084 mL | |
| H2O | 10 mM | 0.2522 mL | 1.2608 mL | 2.5217 mL | 6.3042 mL |
| 15 mM | 0.1681 mL | 0.8406 mL | 1.6811 mL | 4.2028 mL | |
| 20 mM | 0.1261 mL | 0.6304 mL | 1.2608 mL | 3.1521 mL | |
| 25 mM | 0.1009 mL | 0.5043 mL | 1.0087 mL | 2.5217 mL | |
| 30 mM | 0.0841 mL | 0.4203 mL | 0.8406 mL | 2.1014 mL | |
| 40 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5761 mL | |
| 50 mM | 0.0504 mL | 0.2522 mL | 0.5043 mL | 1.2608 mL | |
| 60 mM | 0.0420 mL | 0.2101 mL | 0.4203 mL | 1.0507 mL | |
| 80 mM | 0.0315 mL | 0.1576 mL | 0.3152 mL | 0.7880 mL | |
| 100 mM | 0.0252 mL | 0.1261 mL | 0.2522 mL | 0.6304 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Canrenoate potassium Related Classifications
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