107902-67-0
107902-67-0
Chemical Structure
Tazofelone
Synonym(s): LY 213829
- CAS No.: 107902-67-0
- Formula:C18H27NO2S
- Molecular Weight:321.48
IUPAC Name: 5-(3,5-di-tert-butyl-4-hydroxybenzyl)thiazolidin-4-one
InChIKey: ILMMRHUILQOQGP-UHFFFAOYSA-N
SMILES: O=C1NCSC1CC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Biological Activity: Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2].
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Tazofelone | 99.01% | Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-135231NL-1 -
Similarity Score 0.70
HY-W009347COX-1-IN-3 -
Similarity Score 0.70
HY-101579LY 178002 -
Similarity Score 0.69
HY-103503CGP13501 -
Similarity Score 0.69
HY-103253RLY231617 (Standard) -
Similarity Score 0.68
HY-111060LY231617 free base -
Similarity Score 0.67
HY-103502CGP7930 -
Similarity Score 0.67
HY-W012187R3,5-Di-tert-butyl-4-hydroxybenzaldehyde (Standard) -
Similarity Score 0.66
HY-Y0172RButylated hydroxytoluene (Standard) -
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References
- [1]. Leopold Franz Goetze,et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2.
- [2]. Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25(12):1383-8. [Content Brief]
