1216626-17-3
1216626-17-3
Chemical Structure
Amisulpride-d5
Synonym(s): (Rac)-Aramisulpride-d5;(Rac)-Esamisulpride-d5; DAN 2163-d5
- CAS No.: 1216626-17-3
- Formula:C17H22D5N3O4S
- Molecular Weight:374.51
IUPAC Name: 4-amino-N-((1-(ethyl-d5)pyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide
InChIKey: NTJOBXMMWNYJFB-SGEUAGPISA-N
SMILES: [2H]C([2H])([2H])C([2H])([2H])N(CCC1)C1CNC(C2=C(C=C(C(S(CC)(=O)=O)=C2)N)OC)=O
Biological Activity: Amisulpride-d5 is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].
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Amisulpride-d5 | 98.27% | Amisulpride-d5 is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. | ||||||||||||||||||||
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Amisulpride (Standard) | ≥98% | Amisulpride (Standard) is the analytical standard of Amisulpride. This product is intended for research and analytical applications. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. | ||||||||||||||||||||
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Amisulpride | 99.77% | Amisulpride ((Rac)-Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride (HY-109167) and S-Amisulpride (HY-126068). Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther. 1997 Jan;280(1):83-97. [Content Brief]
