131-70-4
Chemical Structure
Monobutyl phthalate
- CAS No.: 131-70-4
- Formula:C12H14O4
- Molecular Weight:222.24
IUPAC Name: 2-(butoxycarbonyl)benzoic acid
InChIKey: YZBOVSFWWNVKRJ-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=CC=C1C(OCCCC)=O
Biological Activity: Monobutyl phthalate is an orally active metabolite of Di-n-butyl phthalate (HY-Y0304) and an embryotoxic agent. Monobutyl phthalate regulates mesodermal lineage gene expression, inhibits uterine decidualization, reduces fetal testosterone levels without directly binding to the androgen receptor, and induces teratogenic effects during organogenesis. Monobutyl phthalate induces testicular oxidative stress and sperm abnormalities. Monobutyl phthalate can be used in studies of developmental toxicity and male reproductive toxicity[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Monobutyl phthalate | 99.72% | Monobutyl phthalate is an orally active metabolite of Di-n-butyl phthalate (HY-Y0304) and an embryotoxic agent. Monobutyl phthalate regulates mesodermal lineage gene expression, inhibits uterine decidualization, reduces fetal testosterone levels without directly binding to the androgen receptor, and induces teratogenic effects during organogenesis. Monobutyl phthalate induces testicular oxidative stress and sperm abnormalities. Monobutyl phthalate can be used in studies of developmental toxicity and male reproductive toxicity. | ||||||||||||||||||||
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Monobutyl phthalate (Standard) | 99.86% | Monobutyl phthalate (Standard) is the analytical standard of Monobutyl phthalate. This product is intended for research and analytical applications. Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant. | ||||||||||||||||||||
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Monobutyl phthalate-d4 | 98.43% | Monobutyl phthalate-d4 is the deuterium labeled Monobutyl phthalate. Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant. | ||||||||||||||||||||
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References
- [1]. van Dartel DA, et al. Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate. Reproductive toxicology (Elmsford, N.Y.). 2009 Apr;27(2):93-102. [Content Brief]
- [2]. Ema M, et al. Antiandrogenic effects of dibutyl phthalate and its metabolite, monobutyl phthalate, in rats. Congenital anomalies. 2002 Dec;42(4):297-308. [Content Brief]
- [3]. Kim SH, et al. Effects of dibutyl phthalate and monobutyl phthalate on cytotoxicity and differentiation in cultured rat embryonic limb bud cells; protection by antioxidants. J Toxicol Environ Health A. 2002 Mar;65(5-6):461-72.
- [4]. Du J, et al. Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl. The Journal of toxicological sciences. 2017;42(3):319-328.
