136-16-3
136-16-3
Chemical Structure
Oxythiamine
Synonym(s): Hydroxythiamin
- CAS No.: 136-16-3
- Formula:C12H16N3O2S
- Molecular Weight:266.34
IUPAC Name: 5-(2-hydroxyethyl)-4-methyl-3-((2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)methyl)thiazol-3-ium
InChIKey: SRDGSXVLAVRBLU-UHFFFAOYSA-O
SMILES: CC1=C(CCO)SC=[N+]1CC2=CN=C(C)NC2=O
Biological Activity: Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Oxythiamine | 96.28% | Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation. | ||||||||||||||||||||
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Oxythiamine chloride hydrochloride | 96.11% | Oxythiamine (Hydroxythiamine) chloride hydrochloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride hydrochloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride hydrochloride inhibits cancer cell apoptosis and inhibits cell proliferation. | ||||||||||||||||||||
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Oxythiamine chloride | Oxythiamine (Hydroxythiamin) chloride, an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine chloride is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine chloride inhibits cancer cell apoptosis and inhibits cell proliferation. | |||||||||||||||||||||
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Oxythiamine diphosphate | Oxythiamin diphosphate is a potent transketolase (TK) inhibitor. | |||||||||||||||||||||
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Pyrithiamine hydrobromide | 96.61% | Pyrithiamine (hydrobromide) is an inhibitor of thiamine kinase and thiamine pyrophosphate kinase. Pyrithiamine (hydrobromide) competitively inhibits thiamine transport and reduces intracellular levels of thiamine and its phosphates. Pyrithiamine (hydrobromide) is used to study thiamine deficiency with polyneuritic symptoms and Wernicke's encephalopathy. | ||||||||||||||||||||
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N3PT | 98.63% | N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine). | ||||||||||||||||||||
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Thiamine monochloride (Standard) | 99.38% | Thiamine monochloride (Standard) (Vitamin B1 (Standard)) is the analytical standard of Thiamine monochloride (HY-A0100). This product is intended for research and analytical applications. Thiamine monochloride (Vitamin B1) is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives. | ||||||||||||||||||||
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Vitamin B1 monophosphate chloride (Standard) | ≥98% | Vitamin B1 monophosphate (chloride) (Standard) is the analytical standard of Vitamin B1 monophosphate (chloride). This product is intended for research and analytical applications. Vitamin B1 monophosphate (Thiamine monophosphate) chloride is a source of vitamin B1 and can be used in food supplements to enhance nutrition. | ||||||||||||||||||||
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Thiamine nitrate (Standard) | ≥98% | Thiamine nitrate (Standard) is the analytical standard of Thiamine nitrate. This product is intended for research and analytical applications. Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives. | ||||||||||||||||||||
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Thiamine hydrochloride (Standard) | 99.84% | Thiamine (hydrochloride) (Standard) is the analytical standard of Thiamine (hydrochloride). This product is intended for research and analytical applications. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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Thiamine monochloride-13C4 hydrochloride | 98.39% | Thiamine monochloride-13C4 (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. | ||||||||||||||||||||
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References
- [1]. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. [Content Brief]
- [2]. Raïs B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456(1):113-8. [Content Brief]
- [3]. Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16(3):633-641. [Content Brief]
