1392809-08-3
1392809-08-3
Chemical Structure
MRL-871
- CAS No.: 1392809-08-3
- Formula:C22H12ClF3N2O3
- Molecular Weight:444.79
IUPAC Name: 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid
InChIKey: DANLZOIRUUHIIX-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)C2=NN(C3=C2C=CC=C3)C(C4=C(C=CC=C4Cl)C(F)(F)F)=O)O
Biological Activity: MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
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MRL-871 | 99.11% | MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. | ||||||||||||||||||||
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