14152-28-4
Chemical Structure
Prostaglandin A1
- CAS No.: 14152-28-4
- Formula:C20H32O4
- Molecular Weight:336.47
IUPAC Name: 7-((1R,2S)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopent-3-en-1-yl)heptanoic acid
InChIKey: BGKHCLZFGPIKKU-LDDQNKHRSA-N
SMILES: CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C=C1)=O)CCCCCCC(O)=O
Biological Activity: Prostaglandin A1 is a dehydrated derivative of Prostaglandin E1. Prostaglandin A1 exhibits antiviral, anti-inflammatory, antitumor, neuroprotective, and antihypertensive activities. Prostaglandin A1 covalently binds to cysteine residues of target proteins through Michael addition, or activates pathways such as PPARγ and HSPs via transcriptional regulation. Prostaglandin A1 is used in research on Mayaro virus infection, stroke, Alzheimer's disease, neuroblastoma, melanoma, and severe gestational hypertension[1][2][3][4][5][6][7][8][9].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Prostaglandin A1 | 99.40% | Prostaglandin A1 is a dehydrated derivative of Prostaglandin E1. Prostaglandin A1 exhibits antiviral, anti-inflammatory, antitumor, neuroprotective, and antihypertensive activities. Prostaglandin A1 covalently binds to cysteine residues of target proteins through Michael addition, or activates pathways such as PPARγ and HSPs via transcriptional regulation. Prostaglandin A1 is used in research on Mayaro virus infection, stroke, Alzheimer's disease, neuroblastoma, melanoma, and severe gestational hypertension. | ||||||||||||||||||||
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References
- [1]. Bygdeman M, et al. The effect of eight new prostaglandins on human myometrium. Acta Physiol Scand. 1967 Apr;69(4):320-6. [Content Brief]
- [2]. Xu GB, et al. Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPARγ/ABCA1-dependent Cholesterol Efflux Mechanisms. Neurotherapeutics. 2019 Apr;16(2):505-522.
- [3]. Xu GB, et al. Prostaglandin A1 Decreases the Phosphorylation of Tau by Activating Protein Phosphatase 2A via a Michael Addition Mechanism at Cysteine 377. Mol Neurobiol. 2021 Mar;58(3):1114-1127.
- [4]. Caldas LA, et al. Prostaglandin A1 triggers Mayaro virus inhibition and heat shock protein 70 expression in an epithelial cell model. Revista da Sociedade Brasileira de Medicina Tropical. 2018;51(5):584-590.
- [5]. Gouin E, et al. Tumor cell biotransformation products of prostaglandin A1 with growth inhibitory activity. Biochem Biophys Res Commun. 1986 Dec 30;141(3):1254-60.
- [6]. Bregman MD, et al. Dexamethasone, prostaglandin A, and retinoic acid modulation of murine and human melanoma cells grown in soft agar. Journal of the National Cancer Institute. 1983 Nov;71(5):927-32.
- [7]. Thomas SC, et al. Induction of the stress response with prostaglandin A1 increases I-kappaBalpha gene expression. FASEB J. 1998 Oct;12(13):1371-8.
- [8]. Toppozada MK, et al. Treatment of preeclampsia with prostaglandin A1. American journal of obstetrics and gynecology. 1988 Jul;159(1):160-5.
- [9]. Xu XH, et al. Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. Acta pharmacologica Sinica. 2007 Aug;28(8):1097-104.
