1421-65-4
Chemical Structure
Melevodopa hydrochloride
Synonym(s): Levodopa methylester hydrochloride
- CAS No.: 1421-65-4
- Formula:C10H14ClNO4
- Molecular Weight:247.68
IUPAC Name: methyl (S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate hydrochloride
InChIKey: WFGNJLMSYIJWII-FJXQXJEOSA-N
SMILES: N[C@@H](CC1=CC=C(O)C(O)=C1)C(OC)=O.[H]Cl
Biological Activity: Melevodopa (Levodopa methylester) hydrochloride is an orally active methylated prodrug of Levodopa (HY-N0304), a dopamine precursor. When used in combination with Carbidopa (HY-B0311) in an effervescent tablet formulation, Melevodopa hydrochloride inhibits motor fluctuations in Parkinson's disease. Melevodopa hydrochloride suppresses subcutaneous tumor growth, pulmonary metastasis proliferation, and primary mass invasiveness of melanoma. Melevodopa hydrochloride induces lipid peroxidation by increasing malondialdehyde levels in melanoma and improves the survival rate of melanoma-bearing mice. Melevodopa hydrochloride can be used in research related to Parkinson's disease (with motor fluctuations) and melanoma[1][2].
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Melevodopa hydrochloride | 99.76% | Melevodopa (Levodopa methylester) hydrochloride is an orally active methylated prodrug of Levodopa (HY-N0304), a dopamine precursor. When used in combination with Carbidopa (HY-B0311) in an effervescent tablet formulation, Melevodopa hydrochloride inhibits motor fluctuations in Parkinson's disease. Melevodopa hydrochloride suppresses subcutaneous tumor growth, pulmonary metastasis proliferation, and primary mass invasiveness of melanoma. Melevodopa hydrochloride induces lipid peroxidation by increasing malondialdehyde levels in melanoma and improves the survival rate of melanoma-bearing mice. Melevodopa hydrochloride can be used in research related to Parkinson's disease (with motor fluctuations) and melanoma. | ||||||||||||||||||||
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- [1]. Stocchi F, et al. Melevodopa/carbidopa effervescent formulation in the treatment of motor fluctuations in advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 2010 Sep 15;25(12):1881-7. [Content Brief]
- [2]. Meadows GG, et al. Ascorbate in the treatment of experimental transplanted melanoma. The American journal of clinical nutrition. 1991 Dec;54(6 Suppl):1284S-1291S. [Content Brief]
Keywords
