1433901-75-7
1433901-75-7
Chemical Structure
RO6806051
- CAS No.: 1433901-75-7
- Formula:C21H19ClN6
- Molecular Weight:390.87
InChIKey: FXEKONNOBJEKPB-UHFFFAOYSA-N
SMILES: ClC1=CC2=C(N=C(N3CCCCC3)C(C4=NN=NN4)=C2C5=CC=CC=C5)C=C1
Biological Activity: RO6806051 is a selectivity FABP4 and FABP5 inhibitor with human FABP4 Ki values of 0.011 μM and 0.23 μM, and human FABP5 Ki values of 0.086 μM and 1.17 μM. RO6806051 can be used for the research of inflammation-related diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RO6806051 | 99.82% | RO6806051 is a selectivity FABP4 and FABP5 inhibitor with human FABP4 Ki values of 0.011 μM and 0.23 μM, and human FABP5 Ki values of 0.086 μM and 1.17 μM. RO6806051 can be used for the research of inflammation-related diseases. | ||||||||||||||||||||
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References
- [1]. Kühne H, et al. M. Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5092-5097. [Content Brief]
- [2]. He Y, et al. Discovery of Potent and Selective FABP4/5 Inhibitors with an Isoquinolone Scaffold as Potential Therapeutics for Inflammation-Related Diseases. J Med Chem. 2025;68(19):20207-20227. [Content Brief]
- [3]. Chen S, et al. Recent Advances on Small-Molecule Inhibitors of Lipocalin-like Proteins. J Med Chem. 2024;67(7):5144-5167. [Content Brief]
Keywords
