1435893-78-9
Chemical Structure
NoxA1ds
- CAS No.: 1435893-78-9
- Formula:C50H88N14O15
- Molecular Weight:1125.32
IUPAC Name: (3S,6S,9S,12S,18S,21S,24S)-24-((S)-2-((S)-1-(L-glutamyl)pyrrolidine-2-carboxamido)-3-methylbutanamido)-6,12-bis(4-aminobutyl)-3-carbamoyl-18-isobutyl-2,9,21-trimethyl-5,8,11,14,17,20,23-heptaoxo-4,7,10,13,16,19,22-heptaazahexacosan-26-oic acid
InChIKey: DHBOJLLJKHKZGT-XTGVMIFDSA-N
SMILES: CC(C)[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H]1N(CCC1)C([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NoxA1ds | 95.34% | NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors. | ||||||||||||||||||||
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