154189-40-9
Chemical Structure
Sibenadet
Synonym(s): AR-C68397AA free base; AR-C68397XX
- CAS No.: 154189-40-9
- Formula:C22H28N2O5S2
- Molecular Weight:464.60
IUPAC Name: 4-hydroxy-7-(2-((2-((3-phenethoxypropyl)sulfonyl)ethyl)amino)ethyl)benzo[d]thiazol-2(3H)-one
InChIKey: DBCKRBGYGMVSTI-UHFFFAOYSA-N
SMILES: O=C1SC2=C(CCNCCS(=O)(CCCOCCC3=CC=CC=C3)=O)C=CC(O)=C2N1
Biological Activity: Sibenadet (AR-C68397AA free base) is a dual dopamine D2/β2-adrenoceptor agonist with selective β2-adrenoceptor agonism. Sibenadet inhibits capsaicin-induced plasma protein extravasation in rat trachea. Sibenadet suppresses edema from sensory nerve fiber activation by activating β2-adrenoceptor. Sibenadet is promising for research of chronic obstructive pulmonary disease (COPD)[1].
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Sibenadet | Sibenadet (AR-C68397AA free base) is a dual dopamine D2/β2-adrenoceptor agonist with selective β2-adrenoceptor agonism. Sibenadet inhibits capsaicin-induced plasma protein extravasation in rat trachea. Sibenadet suppresses edema from sensory nerve fiber activation by activating β2-adrenoceptor. Sibenadet is promising for research of chronic obstructive pulmonary disease (COPD). | |||||||||||||||||||||
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