1868138-66-2
Chemical Structure
Berberine ursodeoxycholate
Synonym(s): HTD1801; BUDCA
- CAS No.: 1868138-66-2
- Formula:C44H57NO8
- Molecular Weight:727.93
IUPAC Name: 9,10-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium (R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
InChIKey: FHZVFXJRSFLYDY-FUXQPCDDSA-M
SMILES: COC1=C2C=[N+]3C(C4=CC(OCO5)=C5C=C4CC3)=CC2=CC=C1OC.C[C@@]67[C@](CC[C@]7([H])[C@H](C)CCC([O-])=O)([H])[C@@]8([H])[C@@](CC6)([H])[C@@]9([C@](C[C@@H](CC9)O)([H])C[C@@H]8O)C
Biological Activity: Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Berberine ursodeoxycholate | 99.34% | Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes. | ||||||||||||||||||||
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Similarity Score 0.65
HY-N0716BRBerberine sulfate (Standard) -
Similarity Score 0.65
HY-17577Berberine chloride hydrate -
Similarity Score 0.65
HY-18258Berberine chloride -
Similarity Score 0.65
HY-N0716Berberine -
Similarity Score 0.60
HY-125850RBerberrubine chloride (Standard) -
Similarity Score 0.58
HY-N0430ACoptisine Sulfate -
Similarity Score 0.58
HY-N0226AEpiberberine chloride -
Similarity Score 0.58
HY-N0110BPalmatine hydroxide -
Similarity Score 0.58
HY-N0110RPalmatine chloride (Standard) -
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References
- [1]. Harrison SA, et al. A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes. Nat Commun. 2021 Sep 17;12(1):5503. [Content Brief]
- [2]. Di Bisceglie AM, et al. Pharmacokinetics and pharmacodynamics of HTD1801 (berberine ursodeoxycholate, BUDCA) in patients with hyperlipidemia. Lipids Health Dis. 2020 Nov 12;19(1):239. [Content Brief]
