189290-58-2
189290-58-2
Chemical Structure
AG1557
- CAS No.: 189290-58-2
- Formula:C16H14IN3O2
- Molecular Weight:407.21
IUPAC Name: N-(3-iodophenyl)-6,7-dimethoxyquinazolin-4-amine
InChIKey: FGCLAQLIXMAIHT-UHFFFAOYSA-N
SMILES: COC1=CC2=NC=NC(NC3=CC=CC(I)=C3)=C2C=C1OC
Biological Activity: AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194[1][2].
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AG1557 | 99.54% | AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-15769WHI-P180 -
Similarity Score 0.89
HY-13524RAG-1478 (Standard) -
Similarity Score 0.89
HY-14346PD153035 -
Similarity Score 0.89
HY-15769AWHI-P180 hydrochloride -
Similarity Score 0.88
HY-W520740CHEMBL94431 -
Similarity Score 0.88
HY-13524AAG-1478 hydrochloride -
Similarity Score 0.88
HY-12013PD153035 Hydrochloride -
Similarity Score 0.86
HY-108419RWHI-P258 (Standard) -
Similarity Score 0.86
HY-169948BML-265 -
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References
- [1]. Akshada Joshi, et al. Identification of Potential Novel EGFR Inhibitors using a Combination of Pharmacophore and Docking Methods. International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491 Vol 7, Issue 6, 2015
- [2]. Ellis AG, et al. High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma. J Chromatogr B Biomed Sci Appl. 2001 Apr 15;754(1):193-9. [Content Brief]
