19983-28-9

VPC-14228 Chemical Structure
19983-28-9

Chemical Structure

VPC-14228

  • CAS No.: 19983-28-9
  • Formula:C13H14N2OS
  • Molecular Weight:246.33

IUPAC Name: 4-(4-phenylthiazol-2-yl)morpholine

InChIKey: MRNNJVNMXOZEQC-UHFFFAOYSA-N

SMILES: N1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1

Biological Activity: VPC-14228 is an inhibitor that selectively targets androgen receptor DNA binding domain (AR-DBD). VPC-14228 inhibits the interaction between AR and DNA, thereby blocking AR-mediated transcriptional activation. VPC-14228 does not rely on nuclear localization inhibition, but rather inhibits the activity of full-length AR and splice variant AR-V7 by interfering with AR binding to chromatin. And VPC-14228 has high selectivity for other nuclear receptors such as ER and PR. VPC-14228 can be used in the study of prostate cancer[1][2].

Cat. No. Product Name Purity Description Pricing
HY-117669 		VPC-14228 99.36% VPC-14228 is an inhibitor that selectively targets androgen receptor DNA binding domain (AR-DBD). VPC-14228 inhibits the interaction between AR and DNA, thereby blocking AR-mediated transcriptional activation. VPC-14228 does not rely on nuclear localization inhibition, but rather inhibits the activity of full-length AR and splice variant AR-V7 by interfering with AR binding to chromatin. And VPC-14228 has high selectivity for other nuclear receptors such as ER and PR. VPC-14228 can be used in the study of prostate cancer.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

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