199864-86-3
199864-86-3
Chemical Structure
RS-127445 hydrochloride
- CAS No.: 199864-86-3
- Formula:C17H17ClFN3
- Molecular Weight:317.79
IUPAC Name: 4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine hydrochloride
InChIKey: MKJPYBJBPRFMHL-UHFFFAOYSA-N
SMILES: NC1=NC(C(C)C)=CC(C2=C3C=CC=CC3=C(F)C=C2)=N1.[H]Cl
Biological Activity: RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RS-127445 hydrochloride | 99.85% | RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. | ||||||||||||||||||||
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RS-127445 hydrochloride (Standard) | 98.56% | RS-127445 (hydrochloride) (Standard) is the analytical standard of RS-127445 (hydrochloride). This product is intended for research and analytical applications. RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. | ||||||||||||||||||||
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VUF10460 | 99.35% | VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46. | ||||||||||||||||||||
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BMI-1026 | BMI-1026 is a cyclin-dependent kinase 1 (Cdk1) inhibitor with IC50 of 2.3 nM. BMI-1026 induces apoptosis by arresting the G2-M phase. | |||||||||||||||||||||
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NHE3-IN-2 | 98.65% | NHE3-IN-2 is a Na+/H+ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin). | ||||||||||||||||||||
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A1AR antagonist 1 | A1AR antagonist 1 (compound 18g) is a potent A1 adenosine receptor (AR) antagonist with Kis of 2.08, 6.91, and 31.2 nM for hA1, hA2A and hA2B, respectively. | |||||||||||||||||||||
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A1AR antagonist 2 | A1AR antagonist 2 (compound 18h) is a potent A1 adenosine receptor (AR) antagonist with Kis of 1.49, 10.2, and 50.1 nM for hA1, hA2A and hA2B, respectively. | |||||||||||||||||||||
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AChE/hCA I/II-IN-1 | AChE/hCA I/II-IN-1 (Compound 6) is a potent inhibitor of AChE/Hca with IC50 values of 22.21, 60.79 and 66.64 nM for AChE, Hca Ⅰ and Hca Ⅱ. AChE/hCA I/II-IN-1 can be used for the rsearch for glaucoma, Alzheimer's disease, diabetes. | |||||||||||||||||||||
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RS-127445 | 99.95% | RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. | ||||||||||||||||||||
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CAIX/CAXII-IN-2 | CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, with Ki values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively. CAIX/CAXII-IN-2 can be used in cancer research. | |||||||||||||||||||||
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Meridianin C | 99.26% | Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation. | ||||||||||||||||||||
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6-Chloro-4-(2-chlorophenyl)quinazoline-2-carbaldehyde (Standard) | ≥98% | 6-Chloro-4-(2-chlorophenyl)quinazoline-2-carbaldehyde (Standard) is the analytical standard of 6-Chloro-4-(2-chlorophenyl)quinazoline-2-carbaldehyde. This product is intended for research and analytical applications. | ||||||||||||||||||||
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