2009-64-5
Chemical Structure
Neopterin
Synonym(s): D-(+)-Neopterin; D-erythro-Neopterin
- CAS No.: 2009-64-5
- Formula:C9H11N5O4
- Molecular Weight:253.21
IUPAC Name: (1S,2R)-1-(2-amino-4-hydroxypteridin-6-yl)propane-1,2,3-triol
InChIKey: BMQYVXCPAOLZOK-XINAWCOVSA-N
SMILES: OC1=C2C(N=CC([C@H](O)[C@H](O)CO)=N2)=NC(N)=N1
Biological Activity: Neopterin is an immune system activator metabolized by GTP and can be produced by activated macrophages. Neopterin has the potential to resist vascular inflammation and atherosclerosis. Neopterin inhibits the phosphorylation of NF-κB and promotes the expression of PPAR-γ, thereby suppressing the inflammatory response of vascular endothelial cells, reducing the formation of macrophage foam cells, and regulating the migration and proliferation of vascular smooth muscle cells. Neopterin can be used in research fields such as cardiovascular diseases (such as atherosclerosis), inflammation-related diseases and tumor immunomonitoring[1][2][3][4][5].
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Neopterin | 99.95% | Neopterin is an immune system activator metabolized by GTP and can be produced by activated macrophages. Neopterin has the potential to resist vascular inflammation and atherosclerosis. Neopterin inhibits the phosphorylation of NF-κB and promotes the expression of PPAR-γ, thereby suppressing the inflammatory response of vascular endothelial cells, reducing the formation of macrophage foam cells, and regulating the migration and proliferation of vascular smooth muscle cells. Neopterin can be used in research fields such as cardiovascular diseases (such as atherosclerosis), inflammation-related diseases and tumor immunomonitoring. | ||||||||||||||||||||
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Neopterin (Standard) | 99.99% | Neopterin (Standard) is the analytical standard of Neopterin. This product is intended for research and analytical applications. Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation. | ||||||||||||||||||||
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Neopterin-13C5 | 97.53% | Neopterin-13C5 (D-(+)-Neopterin-13C5; D-erythro-Neopterin-13C5) is the deuterium labeled Neopterin (HY-W040055). Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation. | ||||||||||||||||||||
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- [1]. Shirai R, et al. Neopterin Counters Vascular Inflammation and Atherosclerosis. J Am Heart Assoc. 2018 Feb 2;7(3):e007359. [Content Brief]
- [2]. Aisaki K, et al. Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment. Exp Biol Med (Maywood). 2012 Mar;237(3):279-86. [Content Brief]
- [3]. Fuchs D, et al. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases. Crit Rev Clin Lab Sci. 1992;29(3-4):307-41. [Content Brief]
- [4]. Sucher R, et al. Neopterin, a prognostic marker in human malignancies. Cancer Lett. 2010 Jan 1;287(1):13-22. [Content Brief]
- [5]. Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3(2):175-187].
