2014368-93-3
Chemical Structure
I-287
- CAS No.: 2014368-93-3
- Formula:C30H30ClFN4O4
- Molecular Weight:565.04
IUPAC Name: 6-(4-(7-(tert-butyl)-5-(4-chloro-3-fluorophenyl)furo[3,2-b]pyridine-2-carbonyl)-3,3-dimethylpiperazin-1-yl)nicotinic acid
InChIKey: WPJYZCYPCSYODL-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(N2CCN(C(C)(C2)C)C(C3=CC(N=C(C4=CC=C(C(F)=C4)Cl)C=C5C(C)(C)C)=C5O3)=O)C=C1)O
Biological Activity: I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
I-287 | 99.36% | I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.47
HY-111218TRPV1 antagonist 5 -
Similarity Score 0.46
HY-110217BMS-566419 -
Similarity Score 0.46
HY-161706c-Fms-IN-15 -
Similarity Score 0.46
HY-170373RET ligand-1 -
Similarity Score 0.46
HY-128352SMYD3-IN-1 -
Similarity Score 0.44
HY-169051SIRT-IN-5 -
Similarity Score 0.44
HY-141799Dimethyl-F-OICR-9429-COOH -
Similarity Score 0.44
HY-169092PF-07957472 -
Similarity Score 0.44
HY-156022Antitubercular agent-41 -
Explore the MedChemAI to find more analogs
