20575-57-9
20575-57-9
Chemical Structure
Calycosin
Synonym(s): Cyclosin
- CAS No.: 20575-57-9
- Formula:C16H12O5
- Molecular Weight:284.26
IUPAC Name: 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
InChIKey: ZZAJQOPSWWVMBI-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(OC)C(O)=C2)=COC3=CC(O)=CC=C13
Biological Activity: Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Calycosin | 99.96% | Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer. | ||||||||||||||||||||
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Calycosin (Standard) | ≥98% | Calycosin (Standard) is the analytical standard of Calycosin. This product is intended for research and analytical applications. Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer. | ||||||||||||||||||||
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7,3',4'-Trihydroxyisoflavone (Standard) | ≥98% | 7,3',4'-Trihydroxyisoflavone (Standard) is the analytical standard of 7,3',4'-Trihydroxyisoflavone. This product is intended for research and analytical applications. 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities. | ||||||||||||||||||||
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Glycitein (Standard) | ≥98% | Glycitein (Standard) is the analytical standard of Glycitein. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Formononetin (Standard) | 98.79% | Formononetin (Standard) is the analytical standard of Formononetin. This product is intended for research and analytical applications. Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth. | ||||||||||||||||||||
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Koparin | 98.40% | Koparin is a minor isoflavone constituent that can be isolated from the wood of Castanospermum austral. | ||||||||||||||||||||
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3'-Methoxydaidzein | 99.67% | 3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. | ||||||||||||||||||||
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5-Deoxycajanin | 5-Deoxycajanin (Compound 4) is a flavonoid and can be isolated from Eschscholtzia californica. | |||||||||||||||||||||
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7,3'-Dihydroxy-5'-methoxyisoflavone | 7,3'-Dihydroxy-5'-methoxyisoflavone (Pterosonin E) is an arylcoumarin. 7,3'-Dihydroxy-5'-methoxyisoflavone can be used for various biochemical studies. | |||||||||||||||||||||
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Pratensein | 99.92% | Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels. | ||||||||||||||||||||
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7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one | 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one is a dual agonist of PPARα and PPARγ, with an EC50 of 23.10 μM for human PPARα and an EC50 of 22.29 μM for human PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one regulates the expression of lipid metabolism-related genes via PPARα, and modulates the expression of genes associated with glucose homeostasis and adipogenesis via PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one can be used in the research of type 2 diabetes and metabolic syndrome. | |||||||||||||||||||||
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2′-Hydroxyformononetin | 2 '-Hydroxyformononetin is an isoflavone compound. 2 '-Hydroxyformononetin may have anti-inflammatory and antioxidant activities. | |||||||||||||||||||||
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References
- [1]. Zhou Y, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015 Feb 12. [Content Brief]
- [2]. Chen J, et al. Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo. Cancer Lett. 2011 Sep 28;308(2):144-51. [Content Brief]
