2115-91-5
2115-91-5
Chemical Structure
Dendrobine
- CAS No.: 2115-91-5
- Formula:C16H25NO2
- Molecular Weight:263.38
IUPAC Name: (2aS,2a1R,4aS,5R,8R,8aS,9S)-9-isopropyl-2a1,4-dimethyldecahydro-7H-6-oxa-4-aza-5,8-methanocyclopenta[cd]azulen-7-one
InChIKey: RYAHJFGVOCZDEI-UFFNCVEVSA-N
SMILES: O=C1O[C@]2([H])[C@@H](C(C)C)[C@@]1([H])[C@@](CC3)([H])[C@]4(C)[C@@]3([H])CN(C)[C@]24[H]
Biological Activity: Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dendrobine | 99.92% | Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties. | ||||||||||||||||||||
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Dendrobine (Standard) | ≥98% | Dendrobine (Standard) is the analytical standard of Dendrobine. This product is intended for research and analytical applications. Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2 signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties. | ||||||||||||||||||||
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Tuberostemonine | 99.86% | Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP+ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent . | ||||||||||||||||||||
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Dendronobilin B | Dendronobilin B is a sesquiterpene compound that can be isolated from Dendrobium crystallinum. | |||||||||||||||||||||
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Tuberostemonine D | Tuberostemonine D, an alkaloid obtained, can be obtained from the root of Stemona tuberosa. | |||||||||||||||||||||
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2-Oxostenine | 2-Oxostenine (Compound 7) is a stenine-type alkaloid found in the roots of Stemona tuberosa Lour. 2-Oxostenine can weakly inhibit Lipopolysaccharide (HY-D1056)-induced NO production. 2-Oxostenine can be used for the research of inflammation. | |||||||||||||||||||||
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Tuberostemonine A | Tuberostemonine A is a natural product that can be found in Stemona tuberosa. | |||||||||||||||||||||
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Croomine | Croomine is a tuberostemospironine-type alkaloid. Croomine can be found in Stemona tuberosa, Croomia heterosepala, and Croomia japonica. | |||||||||||||||||||||
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Stenine | Stenine (Compound 5) is an alkaloid found in the roots of Stemona sessilifolia. | |||||||||||||||||||||
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10-Hydroxycroomine | 10-Hydroxycroomine is a croomine-type alkaloid. 10-Hydroxycroomine can be isolated from the roots of Stemona tuberosa. 10-Hydroxycroomine produces a non-statistically significant reduction in Citric acid (HY-N1428)-induced coughing. 10-Hydroxycroomine can be used for the research of cough. | |||||||||||||||||||||
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Neotuberostemonine | 99.93% | Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages. | ||||||||||||||||||||
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Neostenine | Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application. | |||||||||||||||||||||
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References
- [1]. Li R, et al. Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action. J Agric Food Chem. 2017 May 10;65(18):3665-3674. [Content Brief]
- [2]. Kim YR, et al., Dendrobine Inhibits γ-Irradiation-Induced Cancer Cell Migration, Invasion and Metastasis in Non-Small Cell Lung Cancer Cells. Biomedicines. 2021 Aug 3;9(8):954. [Content Brief]
- [3]. Zhang CC, et al., Two new alkaloids from Dendrobium nobile Lindl. exhibited neuroprotective activity, and dendrobine alleviated Aβ1-42 -induced apoptosis by inhibiting CDK5 activation in PC12 cells. Drug Dev Res. 2023 Apr;84(2):262-274. [Content Brief]
- [4]. Yue Q, et al., Dendrobine protects HACAT cells from H2O2-induced oxidative stress and apoptosis damage via Nrf2/Keap1/ARE signaling pathway. Toxicol Appl Pharmacol. 2022 Nov 1;454:116217. [Content Brief]
- [5]. Feng Y, et al., Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells. Basic Clin Pharmacol Toxicol. 2021 Mar;128(3):379-385. [Content Brief]
