2139348-60-8
2139348-60-8
Chemical Structure
Pomalidomide-PEG1-C2-COOH
- CAS. Nr.: 2139348-60-8
- Formula:C18H19N3O7
- Molecular Weight:389.36
IUPAC Name: 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid
InChIKey: GXCGXOBFROXMLV-UHFFFAOYSA-N
SMILES: OC(CCOCCNC1=C(C(N(C2C(NC(CC2)=O)=O)C3=O)=O)C3=CC=C1)=O
Biological Activity: Pomalidomide-PEG1-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Pomalidomide-PEG1-C2-COOH | 99.76% | Pomalidomide-PEG1-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. | ||||||||||||||||||||
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Thalidomide-NH-PEG1-NH2 hydrochloride | 99.22% | Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||||||||||||||||||
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Pomalidomide-PEG2-COOH | 99.86% | Pomalidomide-PEG2-COOH (Pomalidomide 4'-PEG2-acid) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. | ||||||||||||||||||||
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Pomalidomide 4'-alkylC3-acid | 98.0% | Pomalidomide 4'-alkylC3-acid is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs. | ||||||||||||||||||||
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Thalidomide-NH-PEG1-NH2 | Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | |||||||||||||||||||||
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Thalidomide-NH-PEG3-propionic acid | 99.15% | Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | ||||||||||||||||||||
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Pomalidomide-C2-acid | 99.78% | Pomalidomide-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. | ||||||||||||||||||||
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Pomalidomide-PEG2-acetic acid | 99.43% | Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) is a conjugate of CRBN ligand Pomalidomide (HY-10984) and a linker. Pomalidomide-PEG2-acetic acid can be used for PROTAC synthesis. | ||||||||||||||||||||
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Thalidomide-4-NH-PEG1-COO(t-Bu) | Thalidomide-4-NH-PEG1-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG1-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules. | |||||||||||||||||||||
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Thalidomide-4-NH-PEG1-COOH TFA | Thalidomide-4-NH-PEG1-COOH TFA is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-4-NH-PEG1-COOH TFA acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-4-NH-PEG1-COOH TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules. | |||||||||||||||||||||
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Pomalidomide-PEG2-OH | Pomalidomide-PEG3-OH (compound 53a) is an E3 Ligase Ligand-Linker Conjugates consisting of a pomalidomide (HY-10984)-based cereblon ligand and a 2-unit PEG linker. | |||||||||||||||||||||
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