2339867-53-5
Chemical Structure
PHD2/HDACs-IN-1
- CAS No.: 2339867-53-5
- Formula:C18H19N9O4
- Molecular Weight:425.40
IUPAC Name: N-hydroxy-2-(4-(6-oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidine-5-carboxamido)piperidin-1-yl)pyrimidine-5-carboxamide
InChIKey: WXBFFCPFJFYHFX-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(N2CCC(NC(C3=CN=C(N4N=CC=C4)NC3=O)=O)CC2)N=C1)NO
Biological Activity: PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC50s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI)[1].
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PHD2/HDACs-IN-1 | PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC50s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI). | |||||||||||||||||||||
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Keywords
