2390475-81-5
2390475-81-5
Chemical Structure
EB-42486
- CAS No.: 2390475-81-5
- Formula:C22H22N8O
- Molecular Weight:414.46
IUPAC Name: 4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide
InChIKey: KHSAHYKLUPESPP-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)N(C)C2=NN=NN2C1(C)C)NC3=CC4=C(NN=C4C5=CC=CC=C5)C=C3
Biological Activity: EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50: < 0.2 nM). EB-42486 can be used in the research of Parkinson's disease[1][2].
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EB-42486 | 99.62% | EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50: < 0.2 nM). EB-42486 can be used in the research of Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839. [Content Brief]
- [2]. Thakur G, et al. Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade. Genes (Basel). 2022 Aug 11;13(8):1426. [Content Brief]
Keywords
