2471981-21-0
2471981-21-0
Chemical Structure
MPO-IN-1
- CAS No.: 2471981-21-0
- Formula:C24H21ClN4
- Molecular Weight:400.90
IUPAC Name: 1-(4-(4-chloro-3-(1H-indol-6-yl)-1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-N,N-dimethylmethanamine
InChIKey: MEHXWAPPUMNIFQ-UHFFFAOYSA-N
SMILES: ClC1=C(C(C2=CC3=C(C=CN3)C=C2)=CN4C5=CC=C(CN(C)C)C=C5)C4=NC=C1
Biological Activity: MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC50s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MPO-IN-1 | 98.07% | MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC50s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.60
HY-147691MPO-IN-5 -
Similarity Score 0.51
HY-12599URMC-099 -
Similarity Score 0.51
HY-184661MMV022224 -
Similarity Score 0.50
HY-111754DMX-5804 -
Similarity Score 0.50
HY-W1142089ActRIIB-IN-2 -
Similarity Score 0.50
HY-W062835CGP77675 -
Similarity Score 0.47
HY-171218CGP062464 -
Similarity Score 0.47
HY-110335OXA-06 hydrochloride -
Similarity Score 0.47
HY-W207224F1386-0303 -
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