265646-85-3
265646-85-3
Chemical Structure
Emidurdar
Synonym(s): Endovion; NS3728
- CAS No.: 265646-85-3
- Formula:C16H9BrF6N6O
- Molecular Weight:495.18
IUPAC Name: 1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)urea
InChIKey: AEFYFGMSRKDXHZ-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(NC2=C(C3=NN=NN3)C=C(Br)C=C2)=O)=C1
Biological Activity: Endovion is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].
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Emidurdar | 99.41% | Endovion is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor. | ||||||||||||||||||||
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Emidurdar (Standard) | ≥98% | Emidurdar (Standard) is the analytical standard of Emidurdar (HY-105917). This product is intended for research and analytical applications. Endovion is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor. | ||||||||||||||||||||
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References
- [1]. Sørensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against CDDP-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. [Content Brief]
- [2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508. [Content Brief]
