2829349-96-2
2829349-96-2
Chemical Structure
FTX-6746
- CAS No.: 2829349-96-2
- Formula:C16H7ClF2N2O
- Molecular Weight:316.69
IUPAC Name: 4-chloro-3-(5,7-difluoro-4-oxo-1,4-dihydroquinolin-2-yl)benzonitrile
InChIKey: PCCCYEBARWZCEY-UHFFFAOYSA-N
SMILES: ClC(C=CC(C#N)=C1)=C1C2=CC(C3=C(F)C=C(F)C=C3N2)=O
Biological Activity: FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FTX-6746 | 99.07% | FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models. | ||||||||||||||||||||
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VU 0360223 | VU 0360223 is a potent metabotropic glutamate receptors (mGluR) negative allosteric modulator with an IC50 of 61 nM. | |||||||||||||||||||||
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Cavosonstat | 99.36% | Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research. | ||||||||||||||||||||
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Tankyrase-IN-2 | 99.06% | Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model. | ||||||||||||||||||||
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Tubulin inhibitor 14 | 95.52% | Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features. | ||||||||||||||||||||
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Tubulin inhibitor 16 | Tubulin inhibitor 16 is a potent tubulin inhibitor. Tubulin inhibitor 16 shows antiproliferative activity. Tubulin inhibitor 16 shows cytotoxicity in HepG2 cells. | |||||||||||||||||||||
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FFN246 | 98.23% | FFN246 is a fluorescent, dual substrate of serotonin transporter (SERT) probe and vesicular monoamine transporter 2 (VMAT2) with excitation and emission spectra 392/427 nm. FFN246 can be used for labeling serotonergic neurons in mouse brain tissue through SERT-dependent accumulation. | ||||||||||||||||||||
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FX-909 | 99.97% | FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. FX-909 can be used for the research of cancer. | ||||||||||||||||||||
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iMQT_020 | 99.45% | iMQT_020 is a selective allosteric SLC1A5_var inhibitor. iMQT_020 disrupts the trimeric assembly of SLC1A5_var, causing metabolic crisis in cancer cells and selectively suppressing their growth. iMQT_020 reduces glutamine anaplerosis and oxidative phosphorylation, resulting in a broad disruption of cancer metabolism. iMQT_020 reduces GSH levels and increases cellular ROS and mitochondrial ROS. iMQT_020 induces apoptosis and ferroptosis. iMQT_020 can epigenetically upregulate PD-L1 expression. iMQT_020 can be used for the study of pancreatic cancer, lung cancer, and colon cancer. | ||||||||||||||||||||
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ERB-196 | 99.89% | ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. | ||||||||||||||||||||
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Zabaglurant | 98.06% | HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively. HTL14242 can be used for the research of parkinson’s disease. | ||||||||||||||||||||
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