2928093-29-0
Chemical Structure
Flonoltinib TFA
Synonym(s): JAK2/FLT3-IN-1 TFA
- CAS No.: 2928093-29-0
- Formula:C27H35F4N7O3
- Molecular Weight:581.61
IUPAC Name: 2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)ethan-1-ol 2,2,2-trifluoroacetate
InChIKey: WIIIAEPAIQXSFK-UHFFFAOYSA-N
SMILES: OCCN(C1CCN(C2=CC=C(NC3=NC=C(C)C(C4=CN(C(C)C)N=C4)=N3)C=C2F)CC1)C.O=C(O)C(F)(F)F
Biological Activity: Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib TFA has anti-cancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Flonoltinib TFA | 98.04% | Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib TFA has anti-cancer activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.90
HY-130247Flonoltinib -
Similarity Score 0.89
HY-130247CFlonoltinib sulfate -
Similarity Score 0.88
HY-130247BFlonoltinib monomaleate -
Similarity Score 0.58
HY-131906JAK2-IN-7 -
Similarity Score 0.55
HY-155746JAK2-IN-9 -
Similarity Score 0.51
HY-115904FLT3/CDK4-IN-1 -
Similarity Score 0.49
HY-115541BRD4-IN-41 -
Similarity Score 0.49
HY-143884JAK2/TYK2-IN-1 -
Similarity Score 0.49
HY-175611FLT3/JAK2/BRD4 ligand-1 -
Explore the MedChemAI to find more analogs
