3056709-95-3
3056709-95-3
Chemical Structure
Polθ/PARP-IN-1
- No. CAS: 3056709-95-3
- Formula:C38H33ClFN7O5S
- Molecular Weight:754.23
InChIKey: BWTOWBOMDHKCDB-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1C2=CC(C)=NC=C2C(NC3=NN=C(S3)OCC4CCN(CC4)C(C5=C(C=CC(CC6=NNC(C7=C6C=CC=C7)=O)=C5)F)=O)=O)Cl
Biological Activity: Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively. Polθ/PARP-IN-1 shows antiproliferative activity. Polθ/PARP-IN-1 induces apoptosis and cell cycle arrest at G2/M phase, causes DNA damage. Polθ/PARP-IN-1 shows anti-tumor activity[1].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Polθ/PARP-IN-1 | 98.89% | Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively. Polθ/PARP-IN-1 shows antiproliferative activity. Polθ/PARP-IN-1 induces apoptosis and cell cycle arrest at G2/M phase, causes DNA damage. Polθ/PARP-IN-1 shows anti-tumor activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.59
HY-170942CDK9/PARP-IN-1 -
Similarity Score 0.58
HY-132885PARP/EZH2-IN-1 -
Similarity Score 0.56
HY-181254PARP1/NAMPT-IN-1 -
Similarity Score 0.55
HY-161372PARP1/c-Met-IN-1 -
Similarity Score 0.55
HY-146336PARP1/2/TNKS1/2-IN-1 -
Similarity Score 0.55
HY-155766PARP1-IN-14 -
Similarity Score 0.53
HY-170972PARP1/NAMPT-IN-2 -
Similarity Score 0.53
HY-141486(Rac)-PROTAC PARP/EGFR ligand 1 -
Similarity Score 0.53
HY-141486APROTAC PARP/EGFR ligand 1 -
Explore the MedChemAI to find more analogs
