313674-97-4
313674-97-4
Chemical Structure
PD-118057
- CAS No.: 313674-97-4
- Formula:C21H17Cl2NO2
- Molecular Weight:386.27
IUPAC Name: 2-((4-(3,4-dichlorophenethyl)phenyl)amino)benzoic acid
InChIKey: ZCQOSCDABPVAFB-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=CC=C1NC2=CC=C(CCC3=CC=C(Cl)C(Cl)=C3)C=C2
Biological Activity: PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PD-118057 | 98.06% | PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability. | ||||||||||||||||||||
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PD-118057 (Standard) | ≥98% | PD-118057 (Standard) is the analytical standard of PD-118057 (HY-108594). This product is intended for research and analytical applications. PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability. | ||||||||||||||||||||
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References
- [1]. Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8(6):e65481. [Content Brief]
- [2]. Yeung SY, et al. Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am J Physiol Cell Physiol. 2007 Jan;292(1):C468-76. [Content Brief]
Keywords
