357399-43-0
357399-43-0
Chemical Structure
Bupropion morpholinol
- CAS No.: 357399-43-0
- Formula:C13H18ClNO2
- Molecular Weight:255.74
IUPAC Name: 2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol
InChIKey: RCOBKSKAZMVBHT-UHFFFAOYSA-N
SMILES: OC1(C2=CC=CC(Cl)=C2)C(C)NC(C)(C)CO1
Biological Activity: Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities[1][2][3].
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Bupropion morpholinol | 99.9% | Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities. | ||||||||||||||||||||
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Bupropion morpholinol-d6 | 99.67% | Bupropion morpholinol-d6 is the deuterated form of Bupropion morpholinol. Bupropion morpholinol is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities. | ||||||||||||||||||||
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References
- [1]. Zhu AZX, et, al. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther. 2012 Dec;92(6):771-7. [Content Brief]
- [2]. Damaj MI, et, al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82. [Content Brief]
- [3]. Damaj MI, et, al. Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. J Pharmacol Exp Ther. 2010 Sep 1;334(3):1087-95. [Content Brief]
