367273-07-2
367273-07-2
Chemical Structure
AGN-195183
Synonym(s): IRX-5183; VTP-195183; NRX-195183
- CAS No.: 367273-07-2
- Formula:C22H22ClF2NO4
- Molecular Weight:437.86
IUPAC Name: 4-(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)-2,6-difluorobenzoic acid
InChIKey: PNAWUIKCVQSLFG-UHFFFAOYSA-N
SMILES: O=C(O)C1=C(F)C=C(NC(C2=C(O)C(Cl)=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F
Biological Activity: AGN-195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AGN-195183 | 99.75% | AGN-195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ. | ||||||||||||||||||||
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AGN 194078 (Standard) | ≥98% | AGN 194078 (Standard) is the analytical standard of AGN 194078 (HY-100273). This product is intended for research and analytical applications. AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. | ||||||||||||||||||||
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LG-100064 | 99.55% | LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer. | ||||||||||||||||||||
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AM580 (GMP) | AM580 (CD336) (GMP) is AM580= (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist. | |||||||||||||||||||||
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BMS 753 (Standard) | BMS 753 (Standard) is the analytical standard of BMS 753 (HY-107395). This product is intended for research and analytical applications. BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a Ki of 2 nM. | |||||||||||||||||||||
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Fluorobexarotene | 99.48% | Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. | ||||||||||||||||||||
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BMS961 | 98.06% | BMS961 is a selective retinoic acid receptor-γ (RARγ) agonist. BMS961 shows anti-inflammatory activity. | ||||||||||||||||||||
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BMS270394 | 98.0% | BMS270394 is a nuclear retinoic acid receptor (RAR-γ) agonist with the EC50 values of 30 nM and 400 nM for humanRAR-γ and RAR-β, respectively. | ||||||||||||||||||||
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Re 80 | Re 80 is an anti-angiogenic agent and is a synthetic retinoid. | |||||||||||||||||||||
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Tamibarotene (Standard) | ≥98% | Tamibarotene (Standard) is the analytical standard of Tamibarotene. This product is intended for research and analytical applications. Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ. | ||||||||||||||||||||
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SRI 6409-94 | 99.25% | SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity. | ||||||||||||||||||||
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