3736-92-3
Chemical Structure
G-25671
- CAS No.: 3736-92-3
- Formula:C23H20N2O2S
- Molecular Weight:388.49
IUPAC Name: 1,2-diphenyl-4-(2-(phenylthio)ethyl)pyrazolidine-3,5-dione
InChIKey: PLGXGMUJUXKCDD-UHFFFAOYSA-N
SMILES: O=C1N(C=2C=CC=CC2)N(C=3C=CC=CC3)C(=O)C1CCSC=4C=CC=CC4
Biological Activity: G-25671 is a platelet cyclooxygenase (COX) inhibitor (Ki = 4.5 μM) and uricosuric agent, as well as the active metabolite of Sulfinpyrazone (HY-B1271). G-25671 reduces the production of thromboxane B2 and malondialdehyde from arachidonic acid (AA), and inhibits human platelet aggregation induced by Sodium arachidonate (HY-109590A). G-25671 can be used in gout-related research[1][2].
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G-25671 | G-25671 is a platelet cyclooxygenase (COX) inhibitor (Ki = 4.5 μM) and uricosuric agent, as well as the active metabolite of Sulfinpyrazone (HY-B1271). G-25671 reduces the production of thromboxane B2 and malondialdehyde from arachidonic acid (AA), and inhibits human platelet aggregation induced by Sodium arachidonate (HY-109590A). G-25671 can be used in gout-related research. | |||||||||||||||||||||
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- [1]. Del Maschio A, et al. Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites. European journal of pharmacology. 1984 Jun 01;101(3-4):209-14. [Content Brief]
- [2]. Halder P, et al. PIDA-mediated N-N bond formation to access pyrazolidine-3,5-diones: a novel process for uricosuric agents G-25671 and sulfinpyrazone. Chemical communications (Cambridge, England). 2023 Jun 29;59(53):8242-8245. [Content Brief]
Keywords
