406-76-8
Chemical Structure
(±)-Carnitine
Synonym(s): DL-Carnitine; DL-Levocarnitine
- CAS 番号: 406-76-8
- Formula:C7H15NO3
- Molecular Weight:161.20
IUPAC Name: 3-hydroxy-4-(trimethylammonio)butanoate
InChIKey: PHIQHXFUZVPYII-UHFFFAOYSA-N
SMILES: C[N+](C)(C)CC(O)CC([O-])=O
Biological Activity: (±)-Carnitine (DL-Carnitine) is an orally effective racemic mixture of L-Carnitine (HY-B0399) and D-Carnitine. (±)-Carnitine elevates the mitochondrial NAD+/NADH ratio in the presence of 1,3-butanediol (HY-77490A). (±)-Carnitine does not increase glucose and urea production from L-glutamine, but stimulates propionate gluconeogenesis in rat renal cortical slices, and significantly reduces hepatic ketone body levels in rats fed a diet containing 30% high fat plus 20% 1,3-butanediol[1][2][3].
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(±)-Carnitine | (±)-Carnitine (DL-Carnitine) is an orally effective racemic mixture of L-Carnitine (HY-B0399) and D-Carnitine. (±)-Carnitine elevates the mitochondrial NAD+/NADH ratio in the presence of 1,3-butanediol (HY-77490A). (±)-Carnitine does not increase glucose and urea production from L-glutamine, but stimulates propionate gluconeogenesis in rat renal cortical slices, and significantly reduces hepatic ketone body levels in rats fed a diet containing 30% high fat plus 20% 1,3-butanediol. | |||||||||||||||||||||
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References
- [1]. Weidemann MJ, et al. Acceleration of gluconeogenesis from propionate by Dl-carnitine in the rat kidney cortex. Biochem J. 1969;111(1):69-81. [Content Brief]
- [2]. Lopes G, et al. Comparative acute effects of l-carnitine and dl-carnitine on hepatic catabolism of l-alanine and l-glutamine in rats. Acta Pharmacol Sin. 2004 Oct;25(10):1257-61. [Content Brief]
- [3]. Mehlman MA, et al. Redox and phosphorylation states and metabolite concentrations in frozen clamped livers of rats fed diets containing 1,3-butanediol and DL-carnitine. J Nutr. 1972 Jan;102(1):45-51. [Content Brief]
