40616-75-9
40616-75-9
Chemical Structure
DSP-4 hydrochloride
Synonym(s): Neurotoxin DSP 4 hydrochloride
- CAS No.: 40616-75-9
- Formula:C11H16BrCl2N
- Molecular Weight:313.06
IUPAC Name: N-(2-bromobenzyl)-2-chloro-N-ethylethan-1-amine hydrochloride
InChIKey: NDDRNRRNYOULND-UHFFFAOYSA-N
SMILES: CCN(CCCl)CC1=CC=CC=C1Br.[H]Cl
Biological Activity: DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DSP-4 hydrochloride | 98.0% | DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons. | ||||||||||||||||||||
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DSP-4 hydrochloride (Standard) | ≥98% | DSP-4 hydrochloride (Standard) is the analytical standard of DSP-4 hydrochloride (HY-103210). This product is intended for research and analytical applications. DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons. | ||||||||||||||||||||
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DSP 4 free base | DSP 4 Free base is a selective neurotoxin that targets noradrenergic neurons in the locus coeruleus noradrenergic system. DSP 4 Free base possesses the unique ability to cross the blood–brain barrier. DSP 4 Free base cyclizes to form a reactive aziridinium derivative that accumulates in noradrenergic neurons. | |||||||||||||||||||||
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PYCR1-IN-1 | 99.65% | PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 µM. PYCR1-IN-1 has anticancer effects. | ||||||||||||||||||||
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Brophenexin free base | 99.24% | Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss. | ||||||||||||||||||||
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PP185 | PP185 is a insulin receptor kinase substrate. PP185 undergoes rapid tyrosine phosphorylation, with activity dependent on divalent cations and inhibited by insulin receptor kinase domain antibodies. PP185 can be used for the research of neuroblastoma. | |||||||||||||||||||||
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Benzeneethanamine,2-bromo-a,a-dimethyl | 97.43% | Benzeneethanamine,2-bromo-a,a-dimethyl (1-(2-Bromophenyl)-2-methylpropan-2-amine) is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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2-(Benzyl(methyl)amino)ethanol (Standard) | ≥98% | 2-(Benzyl(methyl)amino)ethanol (Standard) is the analytical standard of 2-(Benzyl(methyl)amino)ethanol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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N1-Benzyl-N1-methylethane-1,2-diamine | N1-Benzyl-N1-methylethane-1,2-diamine is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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3-[Benzyl(methyl)amino]propanoic acid | 3-[Benzyl(methyl)amino]propanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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FP802 | FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology. FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS). FP802 can be used for AD and ALS research. | |||||||||||||||||||||
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2-Bromoamphetamine hydrochloride | 2-Bromoamphetamine hydrochloride is an isomer of 4-Bromoamphetamine. 4-Bromoamphetamine is a psychoactive substance. | |||||||||||||||||||||
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References
- [1]. Hormigo S, et al. The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats. Front Neural Circuits. 2012 Jun 28;6:41. [Content Brief]
- [2]. Jaim-Etcheverry G, et al. DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 1980 Apr 28;188(2):513-23. [Content Brief]
