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Cat. No.: HY-121602

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DSP 4 free base

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

DSP 4 Free base is a selective neurotoxin that targets noradrenergic neurons in the locus coeruleus noradrenergic system. DSP 4 Free base possesses the unique ability to cross the blood–brain barrier. DSP 4 Free base cyclizes to form a reactive aziridinium derivative that accumulates in noradrenergic neurons.

For research use only. We do not sell to patients.

CAS No.: 62078-98-2
Formula: C₁₁H₁₅BrClN
Molecular Weight:276.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DSP 4 free base Chemical Structure

CAS No.: 62078-98-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Adrenergic Receptor Isoforms :

Chemical Information

CAS No. 62078-98-2
Molecular Weight 276.60
Formula C₁₁H₁₅BrClN
SMILES

ClCCN(CC)CC1=C(Br)C=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Invest Ophthalmol Vis Sci

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice. [Abstract]

2025 Jun 2;66(6):13. PMID: 40465266
Front Mol Neurosci

A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation. [Abstract]

2021 Nov 30:14:752838. PMID: 34916906

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Neurotoxicity of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP 4) on noradrenergic neurons is mimicked by its cyclic aziridinium derivative

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DSP 4 free base

2 Cited Publications

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Publications (2)
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DSP 4 free base

Publications Citing Use of MedChemExpress (MCE) DSP 4 free base

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

DSP 4 free base Related Classifications

Cat. No.: HY-121602