437-50-3
437-50-3
Chemical Structure
Gentisin
- CAS. Nr.: 437-50-3
- Formula:C14H10O5
- Molecular Weight:258.23
IUPAC Name: 1,7-dihydroxy-3-methoxy-9H-xanthen-9-one
InChIKey: XOXYHGOIRWABTC-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC3=C1C=C(O)C=C3)C=C(OC)C=C2O
Biological Activity: Gentisin is a natural compound. Gentisin can be extracted from Gentianae radix (Gentianaceae). Gentisin has mutagenic activity. Gentisin can be used in vascular smooth muscle research[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Gentisin | 98.55% | Gentisin is a natural compound. Gentisin can be extracted from Gentianae radix (Gentianaceae). Gentisin has mutagenic activity. Gentisin can be used in vascular smooth muscle research. | ||||||||||||||||||||
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Gentisein | 98.07% | Gentisein (NSC 329491) is a metabolite of Mangiferin (HY-N0290) that inhibits the serotonin transporter (5-HT uptake system). Gentisein suppresses serotonin uptake and can be used in studies related to depression. | ||||||||||||||||||||
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Isogentisin | 99.18% | Isogentisin is a Monoamine oxidase inhibitor. Isogentisin reduces basal Caspase-3 activity levels. Isogentisin induces mild intracellular oxidative stress, reduces protein oxidation after prolonged incubation, and does not significantly reduce ROS generated by CSE or H2O2. Isogentisin protects cells from cigarette smoke extract-, hydrogen peroxide-, and UV-induced death through cellular interactions rather than chemical neutralization of smoke. Isogentisin can be used in research on endothelial injury. | ||||||||||||||||||||
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GPR40 Activator 3 | GPR40 Activator 3 (compound SC) is a potent GPR40 activator. GPR40 Activator 3 mitigates pulmonary fibrosis by inhibiting M2 macrophage polarization via the GPR40/PKD1/CD36 axis. | |||||||||||||||||||||
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1,3,7-Trihydroxy-2-methoxyxanthone | 1,3,7-Trihydroxy-2-methoxyxanthone is a Xanthones product that can be isolated from the roots of Polygala fallax.. | |||||||||||||||||||||
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Swertianine | Swertianine is a hydroxyexanthone that can be isolated from Swertia decussata. Swertianine has antioxidant activity by inhibiting lipid peroxidation, scavenging DPPH and superoxide free radicals. Swertianine also inhibits γ-ray induced DNA damage of pBR322 with protective effect. | |||||||||||||||||||||
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Methylswertianin | 98.09% | Methylswertianin is an active constituent in Swertia punicea Hemsl, with anti-diabetic effect. Methylswertianin can abates type-2 diabetes, likely via the improvement of insulin resistance (IR). | ||||||||||||||||||||
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Mesuaxanthone A | Mesuaxanthone A is a xanthone with anti-inflammatory activities. Mesuaxanthone A shows typical CNS depressant effects. | |||||||||||||||||||||
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1,5,6-Trihydroxy-3-methoxyxanthone | 1,5,6-Trihydroxy-3-methoxyxanthone is a xanthone that can be found in Hypericum perforatum L.. 1,5,6-Trihydroxy-3-methoxyxanthone shows antioxidant activity and cytotoxicity. | |||||||||||||||||||||
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1,7-Dihydroxy-4-methoxyxanthone | 1,7-Dihydroxy-4-methoxyxanthone is a Xanthones product that can be isolated from the woods of Cratoxylum maingayi.. | |||||||||||||||||||||
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1,7-Dihydroxy-2,3-dimethoxyxanthone | 1,7-Dihydroxy-2,3-dimethoxyxanthone is a xanthone that can be found in Polygala cyparissias. | |||||||||||||||||||||
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References
- [1]. Morimoto, et al. Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae). Mutat Res. 1983 Feb;116(2):103-17. [Content Brief]
- [2]. Waltenberger B, et al. Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation. Molecules. 2015 Nov 13;20(11):20381-90. [Content Brief]
