4547-72-2
4547-72-2
Chemical Structure
Gossypolone
- CAS. Nr.: 4547-72-2
- Formula:C30H26O10
- Molecular Weight:546.52
IUPAC Name: 6,6',7,7'-tetrahydroxy-5,5'-diisopropyl-3,3'-dimethyl-1,1',4,4'-tetraoxo-1,1',4,4'-tetrahydro-[2,2'-binaphthalene]-8,8'-dicarbaldehyde
InChIKey: YSPBCFMMSKAENM-UHFFFAOYSA-N
SMILES: O=CC1=C(C(O)=C(C2=C1C(C(C(C3=O)=C(C(C4=C3C(C=O)=C(C(O)=C4C(C)C)O)=O)C)=C(C2=O)C)=O)C(C)C)O
Biological Activity: Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Gossypolone | 96.28% | Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer. | ||||||||||||||||||||
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Maritinone | Maritinone is a compound with antiproliferative activity and exhibits strong cytostatic activity in various tumor cell lines. | |||||||||||||||||||||
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(-)BI97D6 | (-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells. | |||||||||||||||||||||
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Saroaspidin A | Saroaspidin A is an antibiotic, which can be isolated from Hypericum japonicum thunb. | |||||||||||||||||||||
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Xanthomegnin | Xanthomegnin is a yellow pigment derived from the fungus Trichophyton megnini. | |||||||||||||||||||||
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Ch282-5 | Ch282-5 is an orally active inhibitor targeting the Bcl-2 protein, inducing mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. Ch282-5 exhibits antiproliferative activity against colorectal cancer cells both in vitro and in vivo, and it also inhibits metastasis. Additionally, Ch282-5 enhances Oxaliplatin (HY-17371)-induced autophagy (Autophagy) by downregulating the Mcl-1 protein and increasing platelet count, alleviating adverse effects of Navitoclax (HY-10087). | |||||||||||||||||||||
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Apogossypolone | 98.58% | Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy. Apogossypolone also has antifungal activity. | ||||||||||||||||||||
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Aureoquinone | Aureoquinone is a broad-spectrum protease inhibitor. Aureoquinone inhibits trypsin, papain, thermophilic protease, collagenase and pound-protease, with IC50 values of 11.4 μg/mL, 14.5 μg/mL, 17.8 μg/mL, 7.1 μg/mL, and 8.7 μg/mL, respectively. | |||||||||||||||||||||
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Diospyrin | Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic (apoptosis) activity, glutathione S-transferase (Glutathione S-transferase) inhibitory activity, and topoisomerase (Topoisomerase) I inhibitory activity. Diospyrin is present in the heartwood of various Diospyros plants and can be used for research on Ehrlich ascites carcinoma, acute myeloid leukemia, chronic myeloid leukemia, mammary adenocarcinoma, cervical epithelial carcinoma, malignant cutaneous melanoma, laryngeal epidermoid carcinoma, human osteosarcoma, and human lymphoblastic carcinoma. | |||||||||||||||||||||
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Isodiospyrin | 99.72% | Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities. | ||||||||||||||||||||
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Eucalyptone | 95% | Eucalyptone ((+)-Macrocarpal N) is a Steroids product that can be isolated from the herbs of Nerium indicum. | ||||||||||||||||||||
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