478043-30-0
478043-30-0
Chemical Structure
AMDE-1
- CAS No.: 478043-30-0
- Formula:C18H8ClF6N3
- Molecular Weight:415.72
IUPAC Name: 2-(5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-2-(3-chlorophenyl)acetonitrile
InChIKey: QPWWAOMXYPIDOY-UHFFFAOYSA-N
SMILES: N#CC(C1=NC2=NC(C(F)(F)F)=CC(C(F)(F)F)=C2C=C1)C3=CC=CC(Cl)=C3
Biological Activity: AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer[1].
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AMDE-1 | AMDE-1 is a potent autophagy inducer. AMDE-1 induces autophagy by the AMPK-mTORC1-ULK1 pathway and at the same time inhibited autophagy-mediated degradation by causing lysosome dysfunction. AMDE-1 can be used in research of cancer. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.54
HY-1222045M038 -
Similarity Score 0.52
HY-129123RML318 (Standard) -
Similarity Score 0.48
HY-186054Antimalarial agent 57 -
Similarity Score 0.48
HY-117571Zatolmilast -
Similarity Score 0.48
HY-143409Antimalarial agent 10 -
Similarity Score 0.48
HY-W324493Carboxymefloquine -
Similarity Score 0.47
HY-17437AMefloquine hydrochloride -
Similarity Score 0.47
![4,4′-[2,5-Bis(trifluoromethyl)-1,4-phenylene]bis[pyridine] Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586949.gif)
HY-W5869494,4′-[2,5-Bis(trifluoromethyl)-1,4-phenylene]bis[pyridine] -
Similarity Score 0.47
HY-17437C(Rac)-Mefloquine -
Explore the MedChemAI to find more analogs
![4,4′-[2,5-Bis(trifluoromethyl)-1,4-phenylene]bis[pyridine] Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586949.gif)
