(Rac)-Mefloquine
(Rac)-Mefloquine ((Rac)-Mefloquin) is an orally active NF-κB inhibitor. (Rac)-Mefloquine inhibits the NF-κB and IKK signaling pathways, suppresses NF-κB-Luc luciferase activity, blocks the activation of p65 and IκBα, and reduces the expression of downstream target genes of NF-κB. (Rac)-Mefloquine activates apoptosis-related factors and induces apoptosis in tumor cells. (Rac)-Mefloquine functions as a tumor cell inhibitor. (Rac)-Mefloquine can be used for the research of colorectal cancer.
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- CAS. Nr.: 49752-90-1
- Formel: C17H16F6N2O
- Molecular Weight:378.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | ED50 |
3 μg/mL
Compound: mefloquine
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Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay
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[PMID: 8450319] |
In Vitro
(Rac)-Mefloquine (Mef) inhibits the NF-κB and IKK signaling pathways, suppresses NF-κB-Luc luciferase activity, blocks the activation of p65 and IκBα, and reduces the expression of downstream target genes of NF-κB[1].
(Rac)-Mefloquine activates apoptosis-related factors and induces apoptosis in tumor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 49752-90-1
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Molecular Weight 378.32
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Formel C17H16F6N2O
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SMILES
FC(F)(F)C1=NC2=C(C=CC=C2C(F)(F)F)C(=C1)C(O)C3NCCCC3
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Synonyms
(Rac)-Mefloquin
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(Rac)-Mefloquine Related Classifications
HY-17437C Related Classifications
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