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Cat. No.: HY-17437C

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(Rac)-Mefloquine

(Synonyms: (Rac)-Mefloquin)

(Rac)-Mefloquine ((Rac)-Mefloquin) is an orally active NF-κB inhibitor. (Rac)-Mefloquine inhibits the NF-κB and IKK signaling pathways, suppresses NF-κB-Luc luciferase activity, blocks the activation of p65 and IκBα, and reduces the expression of downstream target genes of NF-κB. (Rac)-Mefloquine activates apoptosis-related factors and induces apoptosis in tumor cells. (Rac)-Mefloquine functions as a tumor cell inhibitor. (Rac)-Mefloquine can be used for the research of colorectal cancer.

For research use only. We do not sell to patients.

CAS No.: 49752-90-1
Formula: C₁₇H₁₆F₆N₂O
Molecular Weight:378.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Mefloquine Chemical Structure

CAS No.: 49752-90-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

All NF-κB Isoforms :

All IKK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	3 μg/mL Compound: mefloquine	Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]

In Vitro

(Rac)-Mefloquine (Mef) inhibits the NF-κB and IKK signaling pathways, suppresses NF-κB-Luc luciferase activity, blocks the activation of p65 and IκBα, and reduces the expression of downstream target genes of NF-κB^[1].
(Rac)-Mefloquine activates apoptosis-related factors and induces apoptosis in tumor cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 49752-90-1
Molecular Weight 378.32
Formula C₁₇H₁₆F₆N₂O
SMILES

FC(F)(F)C1=NC2=C(C=CC=C2C(F)(F)F)C(=C1)C(O)C3NCCCC3
Synonyms

(Rac)-Mefloquin
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu Xin, et al. The application of Mefloquine and its derivative as NF- kB inhibitors. CN107998133A. 2018-05-08.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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(Rac)-Mefloquine

All NF-κB Isoforms

All IKK Isoforms