489-84-9
489-84-9
Chemical Structure
Guaiazulene
- CAS No.: 489-84-9
- Formula:C15H18
- Molecular Weight:198.30
IUPAC Name: 7-isopropyl-1,4-dimethylazulene
InChIKey: FWKQNCXZGNBPFD-UHFFFAOYSA-N
SMILES: CC(C1=CC2=C(C)C=CC2=C(C)C=C1)C
Biological Activity: Guaiazulene is a bicyclic sesquiterpene. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Guaiazulene | 99.08% | Guaiazulene is a bicyclic sesquiterpene. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations. | ||||||||||||||||||||
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Guaiazulene (Standard) | 99.84% | Guaiazulene (Standard) is the analytical standard of Guaiazulene (HY-N6951). This product is intended for research and analytical applications. Guaiazulene is a bicyclic sesquiterpene that can cross the blood-brain barrier. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations. | ||||||||||||||||||||
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Nezukone (Standard) | ≥98% | Nezukone (Standard) is the analytical standard of Nezukone (HY-103708). This product is intended for research and analytical applications. Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron. | ||||||||||||||||||||
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Chamazulene | 98.96% | Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation. | ||||||||||||||||||||
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Carvacrol (Standard) | 99.98% | Carvacrol (Standard) is the analytical standard of Carvacrol. This product is intended for research and analytical applications. Carvacrol is an orally active and blood-brain barrier-permeable monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations. | ||||||||||||||||||||
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γ-Thujaplicin | γ-Thujaplicin is a Hinokitiol (HY-B2230)-related compound that can be isolated from the wood of Thujopsis dolabrata. γ-Thujaplicin shows strong cytotoxic activities against human stomach cancer cell lines KATO-III and Ehrlich’s ascites carcinoma. γ-Thujaplicin exhibits potent and broad-spectrum antifungal activity on wood-rotting fungi, and insecticidal activity on the noxious insects. γ-Thujaplicin can be used for cancer and infection research and pest management. | |||||||||||||||||||||
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Cadalene | Cadalene is a natural product present in the essential oil of Pelargonium sp. (rose-scented geranium) cultivated in Cuba. | |||||||||||||||||||||
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4-Isopropyl-3-methylphenol | 4-Isopropyl-3-methylphenol acts as a biofilm inhibitor, Antibacterial agent, Antifungal agent, and Acaricide. 4-Isopropyl-3-methylphenol reduces the expression levels of biofilm-associated gtfB, gtfD, and gtfC genes. 4-Isopropyl-3-methylphenol disrupts ion and redox homeostasis in fungal cells, and its combination with Octylgallate enhances antifungal activity. 4-Isopropyl-3-methylphenol exhibits fumigant toxicity and direct contact toxicity against Dermatophagoides farinae and Dermatophagoides pteronyssinus. 4-Isopropyl-3-methylphenol is applicable to research related to dental caries and Aspergillus infections/contamination. | |||||||||||||||||||||
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Carvacrol methyl ether (Standard) | ≥98% | Carvacrol methyl ether (Standard) is the analytical standard of Carvacrol methyl ether (HY-W049970). This product is intended for research and analytical applications. Carvacrol methyl ether is a carvacrol derivative isolated from plant essential oils. Carvacrol methyl ether essentially lost its antibacterial activity, exhibiting only a weak inhibitory effect on Saccharomyces cerevisiae at the highest tested concentration of 3 g/L. | ||||||||||||||||||||
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2-Isopropylnaphthalene | 2-Isopropylnaphthalene is a biochemical assay reagent. | |||||||||||||||||||||
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References
- [1]. Togar B, et al. Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J Intercult Ethnopharmacol. 2015 Jan-Mar;4(1):29-33. [Content Brief]
- [2]. Kourounakis AP, et al. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol. 1997 Sep;49(9):938-42. [Content Brief]
- [3]. Ye Q, et al. Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer. Front Pharmacol. 2021 Apr 15;12:621181. [Content Brief]
- [4]. Akram W, et al. Guaiazulene and related compounds: A review of current perspective on biomedical applications. Life Sci. 2023 Mar 1;316:121389. [Content Brief]
