503166-51-6
503166-51-6
Chemical Structure
BMS-566394
- CAS No.: 503166-51-6
- Formula:C22H21F3N4O4
- Molecular Weight:462.42
IUPAC Name: (3R,4R)-N-hydroxy-4-(4-((2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)methyl)benzamido)tetrahydro-2H-pyran-3-carboxamide
InChIKey: PGVYYPZKXKGBLD-JKSUJKDBSA-N
SMILES: O=C(N[C@H](CCOC1)[C@H]1C(NO)=O)C(C=C2)=CC=C2CN3C(C(F)(F)F)=NC4=CC=CC=C34
Biological Activity: BMS-566394 is a selective, orally active TACE (ADAM17) inhibitor. BMS-566394 inhibits LPS-induced TNF-α production in whole blood. BMS-566394 selectively inhibits TACE activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-566394 | 99.95% | BMS-566394 is a selective, orally active TACE (ADAM17) inhibitor. BMS-566394 inhibits LPS-induced TNF-α production in whole blood. BMS-566394 selectively inhibits TACE activity. | ||||||||||||||||||||
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References
- [1]. Sengupta P, et al. Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE. Eur J Med Chem. 2011;46(11):5549-5555. [Content Brief]
- [2]. Moss ML, et al. Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2008;4(6):300-309. [Content Brief]
Keywords
