548-82-3
Chemical Structure
Pinobanksin
Synonym(s): 3,5,7-Trihydroxyflavanone
- CAS No.: 548-82-3
- Formula:C15H12O5
- Molecular Weight:272.25
IUPAC Name: (2R,3R)-3,5,7-trihydroxy-2-phenylchroman-4-one
InChIKey: SUYJZKRQHBQNCA-LSDHHAIUSA-N
SMILES: O=C1[C@H](O)[C@@H](C2=CC=CC=C2)OC3=CC(O)=CC(O)=C13
Biological Activity: Pinobanksin is an antioxidant and anti-ferroptosis agent found in sunflower honey and propolis, with oral activity. Pinobanksin enhances Nrf2-mediated antioxidant defense, inhibits NF-κB inflammation, and suppresses apoptosis and ferroptosis in in vivo models and normal cells. Pinobanksin exhibits apoptosis-inducing effects on B-cell lymphoma cells. Pinobanksin can be used in research related to perfluorooctane sulfonate-induced renal/cardiac toxicity, acute colitis, and B-cell lymphoma[1][2][3][4][5][6].
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Pinobanksin | 99.30% | Pinobanksin is an antioxidant and anti-ferroptosis agent found in sunflower honey and propolis, with oral activity. Pinobanksin enhances Nrf2-mediated antioxidant defense, inhibits NF-κB inflammation, and suppresses apoptosis and ferroptosis in in vivo models and normal cells. Pinobanksin exhibits apoptosis-inducing effects on B-cell lymphoma cells. Pinobanksin can be used in research related to perfluorooctane sulfonate-induced renal/cardiac toxicity, acute colitis, and B-cell lymphoma. | ||||||||||||||||||||
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References
- [1]. Hayat MF, et al. Protective potential of Pinobanksin against perflurooctane sulfonate induced nephrotoxicity via modulating Nrf-2/Keap-1, inflammation and apoptosis. International journal of environmental health research. 2026 May;36(5):1121-1132.
- [2]. Yang D, et al. Pinobanksin alleviates 4℃ semen preservation-induced oxidative damage and apoptosis in Wenchang Pig spermatozoa via the CaMKKβ/AMPK/Nrf2 pathway. Veterinary journal (London, England : 1997). 2026 Apr;316:106599. [Content Brief]
- [3]. Javed M, et al. Pinobanksin ameliorates perfluorooctane sulfonate-evoked cardiotoxicity via targeting Nrf-2/Keap-1, oxidative damage and inflammation in Sprague Dawley rats. Tissue & cell. 2025 Oct;96:102988.
- [4]. Bi H, et al. Pinobanksin ameliorated DSS-induced acute colitis mainly through modulation of SLC7A11/glutathione-mediated intestinal epithelial ferroptosis. Food & function. 2024 May 07;15(9):4970-4982.
- [5]. Sabatier S, et al. Identification of flavonoids in sunflower honey[J]. Journal of Food Science, 1992, 57(3): 773-774.
- [6]. Alday E, et al. Apoptotic induction by pinobanksin and some of its ester derivatives from Sonoran propolis in a B-cell lymphoma cell line. Chemico-biological interactions. 2015 Dec 05;242:35-44. [Content Brief]
