554-01-8
554-01-8
Chemical Structure
5-Methylcytosine
- CAS No.: 554-01-8
- Formula:C5H7N3O
- Molecular Weight:125.13
IUPAC Name: 6-amino-5-methylpyrimidin-2(1H)-one
InChIKey: LRSASMSXMSNRBT-UHFFFAOYSA-N
SMILES: O=C1N=CC(C)=C(N)N1
Biological Activity: 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma[1][2][3][4].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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5-Methylcytosine | 99.94% | 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma. | ||||||||||||||||||||
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5-Methylcytosine (Standard) | 98.80% | 5-Methylcytosine (Standard) is the analytical standard of 5-Methylcytosine (HY-W008091). This product is intended for research and analytical applications. 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma. | ||||||||||||||||||||
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5-Methylcytosine-d4 | 99% | 5-Methylcytosine-d4 is the deuterium labeled 5-Methylcytosine (HY-W008091). 5-Methylcytosine is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma. | ||||||||||||||||||||
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5-Formylcytosine | 96.4% | 5-Formylcytosine is a modified base, which is oxidized from 5-methylcytosine. 5-Formylcytosine is a intermediate of in the active DNA demethylation. | ||||||||||||||||||||
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5-Hydroxycytosine-13C,15N2 | 5-Hydroxycytosine-13C,15N2 is the 13C and 15N labeled 5-Hydroxycytosine. | |||||||||||||||||||||
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Flucytosine-13C,15N2 | Flucytosine-13C,15N2 (NSC 103805-13C,15N2; Ro 2-9915-13C,15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139). | |||||||||||||||||||||
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Cytosine-13C2,15N3 | Cytosine-13C2,15N3 is the 13C-labeled and 15N-labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. | |||||||||||||||||||||
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Cytosine-d2 | 99.97% | Cytosine-d2 is the deuterium labeled Cytosine. Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging. | ||||||||||||||||||||
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5-Hydroxymethyluracil-d3 | 99% | 5-Hydroxymethyluracil-d3 is the deuterium labeled 5-Hydroxymethyluracil. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase. | ||||||||||||||||||||
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5-Methylcytosine hydrochloride | 99.57% | 5-Methylcytosine hydrochloride is a well-characterized DNA modification in prokaryotes and eukaryotes. 5-Methylcytosine hydrochloride forms symmetrical methylation on CpG dinucleotides in DNA, stabilizes tRNA/rRNA structure in RNA, and affects mRNA translation. 5-Methylcytosine hydrochloride can be oxidized to generate 5hmC, 5fC, and 5caC. 5-Methylcytosine hydrochloride can be used in epigenetics, developmental biology, and the study of diseases such as colorectal cancer and hepatocellular carcinoma. | ||||||||||||||||||||
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Thymine-d4 | Thymine-d4 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM. | |||||||||||||||||||||
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Thymine-d4-1 | 99.47% | Thymine-d4-1 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM. | ||||||||||||||||||||
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5-Hydroxymethylcytosine | 98.14% | 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes). | ||||||||||||||||||||
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2-Methylpyrazine-d6 | 98.81% | 2-Methylpyrazine-d6 is the deuterium labeled 2-Methylpyrazine. 2-Methylpyrazine is a kind of alkylpyrazine that can be identified in roasted red pepper seed oils. | ||||||||||||||||||||
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5-Bromo-4-methylpyrimidin-2-ol | 5-Bromo-4-methylpyrimidin-2-ol is a biomolecule. | |||||||||||||||||||||
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6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione-d3 | 6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione-d3 (6-Amino-3-methyluracil-d3) is the deuterium labeled 6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione (HY-W038777). | |||||||||||||||||||||
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2-Chloro-5-methylpyrimidin-4-amine-15N2,13C | 2-Chloro-5-methylpyrimidin-4-amine-15N2,13C (4-Amino-2-chloro-5-methylpyrimidine-15N2,13C) is the 13C- and 15N-labeled 2-Chloro-5-methylpyrimidin-4-amine (HY-W002966). | |||||||||||||||||||||
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5-Methyl cytosine-13C,15N2 hydrochloride | 99.31% | 5-Methyl cytosine-13C,15N2 hydrochloride (5-Methylcytosine hydrochloride-13C,15N2) is the 13C- and 15N-labeled 5-Methylcytosine hydrochloride (HY-W008091A). 5-Methylcytosine hydrochloride plays a crucial role in regulating gene expression, facilitating genomic imprinting, and suppressing transposable elements, while also being intricately linked to translational fidelity and tRNA recognition. | ||||||||||||||||||||
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5-Azacytosine (Standard) | ≥98% | 5-Azacytosine (Standard) is the analytical standard of 5-Azacytosine. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Cui X, et al. 5-Methylcytosine RNA Methylation in Arabidopsis Thaliana. Mol Plant. 2017 Nov 6;10(11):1387-1399. [Content Brief]
- [2]. Breiling A, et al. Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond. Epigenetics Chromatin. 2015 Jul 21;8:24. [Content Brief]
- [3]. Edelheit S, et al. Transcriptome-wide mapping of 5-methylcytidine RNA modifications in bacteria, archaea, and yeast reveals m5C within archaeal mRNAs. PLoS Genet. 2013 Jun;9(6):e1003602. [Content Brief]
- [4]. Huang W, et al. Formation and determination of the oxidation products of 5-methylcytosine in RNA. Chem Sci. 2016 Aug 1;7(8):5495-5502. [Content Brief]
