55804-74-5
Chemical Structure
Clitorin
- CAS No.: 55804-74-5
- Formula:C33H40O19
- Molecular Weight:740.66
IUPAC Name: 3-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChIKey: WRXVPTMENPZUIZ-QEZWUOJGSA-N
SMILES: O=C1C(O[C@H]2[C@@H]([C@H]([C@H](O)[C@@H](CO[C@H]3[C@@H]([C@@H]([C@@H](O)[C@H](C)O3)O)O)O2)O)O[C@@]4([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O4)O)O)=C(C5=CC=C(O)C=C5)OC6=CC(O)=CC(O)=C61
Biological Activity: Clitorin is an orally active flavonoid compound that can be isolated from Carica papaya. Clitorin is an inhibitor of EGFR (IC50: 89.58 nM) and aromatase (IC50: 77.41 nM). Clitorin has antioxidant and anti-tumor activities. In the DPPH and ABTS radical scavenging assays, Clitorin has IC50 values of 91.96 ppm and 250.45 ppm, respectively. In addition, Clitorin can regulate lipogenesis and fatty acid oxidation and can be used in the research of non-alcoholic fatty liver disease[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Clitorin | 99.45% | Clitorin is an orally active flavonoid compound that can be isolated from Carica papaya. Clitorin is an inhibitor of EGFR (IC50: 89.58 nM) and aromatase (IC50: 77.41 nM). Clitorin has antioxidant and anti-tumor activities. In the DPPH and ABTS radical scavenging assays, Clitorin has IC50 values of 91.96 ppm and 250.45 ppm, respectively. In addition, Clitorin can regulate lipogenesis and fatty acid oxidation and can be used in the research of non-alcoholic fatty liver disease. | ||||||||||||||||||||
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Oxytroflavoside G | Oxytroflavoside G (compound 5) can be isolated from Magnolia utilis. | |||||||||||||||||||||
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Camelliaside A (Standard) | ≥98% | Camelliaside A (Standard) is the analytical standard of Camelliaside A. This product is intended for research and analytical applications. Camelliaside A is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace. | ||||||||||||||||||||
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Camelliaside B | 99.43% | Camelliaside B is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace. | ||||||||||||||||||||
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Mauritianin | 99.83% | Mauritianin is an orally active kaempferol glycoside. Mauritianin can be isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor. Mauritianin has hepatoprotective, neuroprotective, and renoprotective activities. Mauritianin increases vascular tone when used in combination with Alcesefoliside (HY-N5049). | ||||||||||||||||||||
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Alcesefoliside | 97.38% | Alcesefoliside is a flavonoid isolated from Nitraria sibirica Pall, with antioxidant activity. | ||||||||||||||||||||
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Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside | 98.37% | Kaempferol-3-O-(2''-O-β-D-glucopyl)-β-D-rutinoside is a natural glycoside that could be found in Camellia oleifera seeds. | ||||||||||||||||||||
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Manghaslin | 98.76% | Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against AChE with an IC50 of 94.92 μM. | ||||||||||||||||||||
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Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside | 99.29% | Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside is an antioxidant with an IC50 of 26.6 μM (DPPH assay). | ||||||||||||||||||||
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Plantanone B | 99.16% | Plantanone B is a moderate antioxidant-agent with an IC50 of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research. | ||||||||||||||||||||
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Kaempferol 3-O-rhamninoside | Kaempferol 3-O-rhamninoside is a Flavonoids product that can be isolated from the seeds of Patrinia villosa (Thunb.) Juss.. | |||||||||||||||||||||
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References
- [1]. Hamed ANE, et al. Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFRwt and aromatase (CYP19A) inhibitors; a study supported by molecular docking. RSC Adv. 2022 Mar 23;12(15):9154-9162. [Content Brief]
- [2]. Cominguez DC, et al. Clitorin ameliorates western diet-induced hepatic steatosis by regulating lipogenesis and fatty acid oxidation in vivo and in vitro. Sci Rep. 2022 Mar 9;12(1):4154. [Content Brief]
- [3]. Teh B P, et al. Clitorin and manghaslin from Carica papaya leaf juice: characterisation and antioxidant properties. 2023.
