56258-32-3
Chemical Structure
Altertoxin I
Synonym(s): Dihydroalterperylenol; ATX-I
- CAS No.: 56258-32-3
- Formula:C20H16O6
- Molecular Weight:352.34
IUPAC Name: (1S,12aR,12bS)-1,4,9,12a-tetrahydroxy-1,2,11,12,12a,12b-hexahydroperylene-3,10-dione
InChIKey: GJIALGLHOBXNAT-KPOBHBOGSA-N
SMILES: O=C(C1=C2C3=CC=C1O)CC[C@]2([C@@]([H])(C4=C3C=CC(O)=C45)[C@H](CC5=O)O)O
Biological Activity: Altertoxin I (Dihydroalterperylenol; ATX-I) is a quinone mycotoxin with immunosuppressive, mutagenic and anticancer activities. Altertoxin I inhibits LPS (HY-D1056)-mediated NF-κB activation and estrogen-dependent alkaline phosphatase activity. Altertoxin I activates the AhR signaling pathway, induces the expression of CYP 1A1/1A2/1B1 and the enzymatic activity of EROD. Altertoxin I can be used in breast cancer research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Altertoxin I | 99.16% | Altertoxin I (Dihydroalterperylenol; ATX-I) is a quinone mycotoxin with immunosuppressive, mutagenic and anticancer activities. Altertoxin I inhibits LPS (HY-D1056)-mediated NF-κB activation and estrogen-dependent alkaline phosphatase activity. Altertoxin I activates the AhR signaling pathway, induces the expression of CYP 1A1/1A2/1B1 and the enzymatic activity of EROD. Altertoxin I can be used in breast cancer research. | ||||||||||||||||||||
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References
- [1]. Crudo F, et al. Discovery of the Alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro. Archives of toxicology. 2025 Jan;99(1):407-421. [Content Brief]
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[2]. Hohenbichler J, et al Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro. Biomolecules. 2020 Jul 9;10(7):1018.
[Content Brief] - [3]. Xi J, et al. Alterperylenol as a Novel Thioredoxin Reductase Inhibitor Induces Liver Cancer Cell Apoptosis and Ferroptosis. Journal of agricultural and food chemistry. 2022 Dec 21;70(50):15763-15775. [Content Brief]
