6240-11-5
Chemical Structure
1-Adamantaneethanol
- CAS No.: 6240-11-5
- Formula:C12H20O
- Molecular Weight:180.29
IUPAC Name: 2-((3r,5r,7r)-adamantan-1-yl)ethan-1-ol
InChIKey: ZBIDZPHRNBZTLT-VBLDAPLVSA-N
SMILES: OCCC12C[C@H]3C[C@@H](C2)C[C@@H](C1)C3
Biological Activity:
1-Adamantaneethanol is an allele-selective MHC II class molecule loading enhancer (MHC loading enhancer, MLE) that enhances peptide loading and ligand exchange of HLA-DR molecules. 1-Adamantaneethanol targets the polymorphic P1 pocket of HLA-DR molecules and preferentially acts on HLA-DR subtypes with Gly at position β86, thereby stabilizing the peptide-receptor conformation and accelerating antigen loading. 1-Adamantaneethanol can be used in studies related to MHC II antigen presentation, peptide vaccines, adaptive immunity and tumor immunity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-Adamantaneethanol | 99.82% | 1-Adamantaneethanol is an allele-selective MHC II class molecule loading enhancer (MHC loading enhancer, MLE) that enhances peptide loading and ligand exchange of HLA-DR molecules. 1-Adamantaneethanol targets the polymorphic P1 pocket of HLA-DR molecules and preferentially acts on HLA-DR subtypes with Gly at position β86, thereby stabilizing the peptide-receptor conformation and accelerating antigen loading. 1-Adamantaneethanol can be used in studies related to MHC II antigen presentation, peptide vaccines, adaptive immunity and tumor immunity. |
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- [1]. Höpner S, et al. Small Organic Compounds Enhance Antigen Loading of Class II Major Histocompatibility Complex Proteins by Targeting the Polymorphic P1 Pocket. Journal of Biological Chemistry. 2006;281(50):38535-38542. [Content Brief]
- [2]. Dickhaut K, et al. Enhancement of Tumour-Specific Immune Responses In Vivo by ‘MHC Loading-Enhancer’ (MLE). PLoS ONE. 2009;4(9):e6811.
Keywords
