630124-46-8

AST 487 Chemical Structure
630124-46-8

Chemical Structure

AST 487

Synonym(s): NVP-AST 487

  • CAS No.: 630124-46-8
  • Formula:C26H30F3N7O2
  • Molecular Weight:529.56

IUPAC Name: 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea

InChIKey: ODPGGGTTYSGTGO-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(OC2=NC=NC(NC)=C2)C=C1)NC3=CC=C(CN4CCN(CC)CC4)C(C(F)(F)F)=C3

Biological Activity: AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.

Cat. No. Product Name Purity Description Pricing
HY-15002 		AST 487 98.90% AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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