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Cat. No.: HY-111286

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WNK-IN-2

WNK-IN-2 is an ATP-competitive WNK kinase inhibitor with low kinase selectivity.

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CAS No.: 853298-47-2
Formule: C₂₇H₃₂F₃N₇O₂
Masse moléculaire:543.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WNK-IN-2 Chemical Structure

CAS No.: 853298-47-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

WNK-IN-2 is an ATP-competitive WNK kinase inhibitor with low kinase selectivity^[1].

In Vitro

WNK-IN-2 (compound 3) exhibits low selectivity for WNK1 and shows stronger inhibitory activity against multiple off-target kinases in a screening panel containing 31 kinases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 853298-47-2
Masse moléculaire 543.60
Formule C₂₇H₃₂F₃N₇O₂
SMILES

O=C(NC1=CC=C(OC2=NC(=NC=C2)NC)C=C1)NC3=CC=C(C(=C3)C(F)(F)F)CN4CCN(CC4)C(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yamada K, et al. Discovery and Characterization of Allosteric WNK Kinase Inhibitors. ACS Chem Biol. 2016;11(12):3338-3346. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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