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Cat. No.: HY-111286

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WNK-IN-2

WNK-IN-2 is an ATP-competitive WNK kinase inhibitor with low kinase selectivity.

For research use only. We do not sell to patients.

CAS No.: 853298-47-2
Formula: C₂₇H₃₂F₃N₇O₂
Molecular Weight:543.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WNK-IN-2 Chemical Structure

CAS No.: 853298-47-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

WNK-IN-2 is an ATP-competitive WNK kinase inhibitor with low kinase selectivity^[1].

In Vitro

WNK-IN-2 (compound 3) exhibits low selectivity for WNK1 and shows stronger inhibitory activity against multiple off-target kinases in a screening panel containing 31 kinases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 853298-47-2
Molecular Weight 543.60
Formula C₂₇H₃₂F₃N₇O₂
SMILES

O=C(NC1=CC=C(OC2=NC(=NC=C2)NC)C=C1)NC3=CC=C(C(=C3)C(F)(F)F)CN4CCN(CC4)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yamada K, et al. Discovery and Characterization of Allosteric WNK Kinase Inhibitors. ACS Chem Biol. 2016;11(12):3338-3346. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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