7329-52-4
7329-52-4
Chemical Structure
Guaiacol-d4
Synonym(s): 2-Methoxyphenol-d4
- CAS No.: 7329-52-4
- Formula:C7H4D4O2
- Molecular Weight:128.16
IUPAC Name: 2-methoxyphen-3,4,5,6-d4-ol
InChIKey: LHGVFZTZFXWLCP-QFFDRWTDSA-N
SMILES: COC1=C(C([2H])=C([2H])C([2H])=C1[2H])O
Biological Activity: Guaiacol-d4 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].
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Guaiacol-d4 | Guaiacol-d4 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity. | |||||||||||||||||||||
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Guaiacol (Standard) | 99.70% | Guaiacol (Standard) is the analytical standard of Guaiacol. This product is intended for research and analytical applications. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity. | ||||||||||||||||||||
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Guaiacol-d4-1 | Guaiacol-d4-1 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity. | |||||||||||||||||||||
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Guaiacol-d7 | Guaiacol-d7 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity. | |||||||||||||||||||||
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Guaiacol-13C6 | Guaiacol-13C6 is the 13C labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity. | |||||||||||||||||||||
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Guaiacol-d3 | 98.67% | Guaiacol-d3 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity. | ||||||||||||||||||||
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Guaiacol | 99.96% | Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity. | ||||||||||||||||||||
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Mequinol (Standard) | ≥98% | Mequinol (Standard) is the analytical standard of Mequinol. This product is intended for research and analytical applications. Mequinol (4-Methoxyphenol)yes MercurialisOne of the bioactive ingredients, mainly used for skin discoloration. MequinolIs an antioxidant that has additive/synergistic effects on carcinogenesis when combined with other phenolic antioxidants. Mequinolalso promote hERαDependent chaperone production with potential estrogenic activity. | ||||||||||||||||||||
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2-Methoxybenzaldehyde-d3 | 2-Methoxybenzaldehyde-d3 is the deuterium labeled 2-Methoxybenzaldehyde. 2-Methoxybenzaldehyde (o-Anisaldehyde), isolated from cinnamon essential oil (CEO), exists antibacterial and antifungal activity. | |||||||||||||||||||||
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Veratrole (Standard) | ≥98% | Veratrole (Standard) is the analytical standard of Veratrole. This product is intended for research and analytical applications. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii. | ||||||||||||||||||||
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Isovanillin-d3 | 99.83% | Isovanillin-d3 is the deuterium labeled Isovanillin. Isovanillin is an aldehyde oxidase inhibitor. Antispasmodic activities. Antidiarrheal activities. | ||||||||||||||||||||
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Vanillin-13C,d3 | 99.42% | Vanillin-13C,d3 is the 13C and deuterium labeled Vanillin. Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine. | ||||||||||||||||||||
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2-Methoxybenzoic acid-d3 | 2-Methoxybenzoic acid (NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether)-d3 is deuterium-labeled 2-Methoxybenzoic acid (HY-N1393). 2-Methoxybenzoic acid is a natural compound with potential salicylate-like effect. 2-Methoxybenzoic acid inhibits carbonic anhydrase activity, elevates intraplatelet cyclic guanosine monophosphate level, and suppresses cytosolic phospholipase A2 phosphorylation. 2-Methoxybenzoic acid suppresses platelet reactivity, including decreased spreading, retraction, and aggregation in platelets. 2-Methoxybenzoic acid ameliorates arterial thrombosis in a dose-dependent manner without affecting normal hemostasis in mice. 2-Methoxybenzoic acid can be used for the research of arterial thrombosis. | |||||||||||||||||||||
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2-Methoxyhydroquinone | 99.57% | 2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced production of chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. 2-Methoxyhydroquinone is also a precursor in the synthesis of the Hsp90 inhibitor Geldanamycin (HY-15230). | ||||||||||||||||||||
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1-Bromo-3-methoxybenzene-d3 | 1-Bromo-3-methoxybenzene-d3 is the deuterium labeled 1-Bromo-3-methoxybenzene. | |||||||||||||||||||||
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1-Chloro-2-methoxybenzene-d3 | 1-Chloro-2-methoxybenzene-d3 is the deuterium labeled 1-Chloro-2-methoxybenzene. | |||||||||||||||||||||
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2-Ethoxyphenol | 99.90% | 2-Ethoxyphenol, also known as guaiacol ethyl ether, consists of a phenolic ring and an ethoxy group connected to the 2-position. The compound has a sweet, smoky flavor and is commonly used as a flavoring in foods such as baked goods, candy and beverages. | ||||||||||||||||||||
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2-Ethoxyphenol-d5 | 2-Ethoxyphenol-d5 is the deuterium labeled 2-Ethoxyphenol. | |||||||||||||||||||||
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2-Methylanisole | 99.0% | 2-Methylanisole is a monomethoxybenzene and acts as an intermediate for the preparation of compounds with methylhydroquinone core . | ||||||||||||||||||||
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Creosol (Standard) | ≥98% | Creosol (Standard) (2-Methoxy-4-methylphenol (Standard)) is the analytical standard of Creosol (HY-W040971). This product is intended for research and analytical applications. Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable. | ||||||||||||||||||||
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3-Methoxycatechol (Standard) | 99.34% | 3-Methoxycatechol (Standard) is the analytical standard of 3-Methoxycatechol (HY-W116576). This product is intended for research and analytical applications. 3-Methoxycatechol is a catechol derivative with endothelium-dependent vasodilatory and antihypertensive activities. 3-Methoxycatechol activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. 3-Methoxycatechol inhibits tau self-interaction and scavenges free radicals such as DPPH. 3-Methoxycatechol combined with NaNO2 enhances forestomach proliferative lesions and papilloma formation, reduces glandular stomach lesions, and promotes esophageal lesion development. 3-Methoxycatechol can be used for research related to hypertension and papilloma. | ||||||||||||||||||||
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2-(Methoxy)-4-vinylphenol-d3 | 98.13% | 2-(Methoxy-d3)-4-vinylphenol is deuterated labeled 2-(Methoxy)-4-vinylphenol. | ||||||||||||||||||||
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3-Methoxyphenol (Standard) | ≥98% | 3-Methoxyphenol (Standard) is the analytical standard of 3-Methoxyphenol (HY-Y1840). This product is intended for research and analytical applications. 3-Methoxyphenol is an environmental pollutant. 3-Methoxyphenol occurs in the aroma components of dried bonito. 3-Methoxyphenol potentially enhances GABA-evoked responses of α1β1 GABAA receptors by increasing the affinity of GABA binding sites. 3-Methoxyphenol is used as a flavoring substance in food and animal feed. 3-Methoxyphenol prolongs pentobarbital-induced sleeping time and reduces elevated plus maze behavior. | ||||||||||||||||||||
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3-Methoxyphenol-d3 | 3-Methoxyphenol-d3 is the d3-labeled 3-Methoxyphenol (HY-Y1840). 3-Methoxyphenol is an environmental pollutant. 3-Methoxyphenol occurs in the aroma components of dried bonito. 3-Methoxyphenol potentially enhances GABA-evoked responses of α1β1 GABAA receptors by increasing the affinity of GABA binding sites. 3-Methoxyphenol is used as a flavoring substance in food and animal feed. 3-Methoxyphenol prolongs pentobarbital-induced sleeping time and reduces elevated plus maze behavior. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7. [Content Brief]
